아스피린 흡입 기관지 유발시험에서 후기 단독 양성 반응을 보인 아스피린 과민성 천식 1예

Abstract

Aspirin and other non-steroidal anti-inflammatory agents (NSAIDs) cause bronchoconstriction in 10% to 20% of the adult asthmatic patients. The lysine-aspirin bronchial provocation test (L-ASA BPT) has become a widely used diagnostic test for detecting aspirin sensitivity in asthmatic patients. Several investigators have reported the development oflate and dual asthmatic responses as well as early asthmatic response. Most late asthmatic responses are known to occur within 4 to 6 hours of the L-ASA BPT. We report a case of aspirin-intolerant asthma with late only response during the L-ASA BPT. The late responses were notedtwice at 4 (greater than 20% decrease of FEV1) and 13 hours (greater than 30∼50% decrease of PFR with dyspnea) after the L-ASA BPT. In conclusion, we suggest that follow-up lung function monitoring will be needed for more than 12 hours after the L-ASA BPT to confirm delayed late asthmatic response. (Korean J Asthma Allergy Clin Immunol 2010;30:329-332)