Cited 10 times in
The impact of artificial tears containing hydroxypropyl guar on mucous layer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남기현 | - |
dc.date.accessioned | 2015-04-23T17:41:50Z | - |
dc.date.available | 2015-04-23T17:41:50Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0277-3740 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102956 | - |
dc.description.abstract | PURPOSE: The aim of this study was to investigate the effect of lubricant eyedrops containing propylene glycol 400 (PEG) and polyethylene glycol (PG) with hydroxypropyl guar (HP-guar) as a gelling agent on the precorneal mucous layer in vivo. METHODS: Sixteen New Zealand white rabbits were randomly assigned to 1 of 4 groups. All rabbits received PEG/PG/HP-guar tear products in the right eye. PEG/PG/HP-guar with Polyquad, 0.1% hyaluronate sodium, 0.5% carboxymethylcellulose, or phosphate-buffered saline was placed in the left eyes of animals in each group. All eyedrops were used 4 times a day for 7 days. An additional 8 rabbits were randomly assigned to 1 of 2 groups. One group received PEG/PG/HP-guar products 4 times a day for 7 days (long-term exposure group), and the other group received PEG/PG/HP-guar products 3 times at 5-minute intervals (short-term exposure group). Fifteen minutes after the last drop was administered, each cornea was immediately excised and mucous layer thickness measured by transmission electron microscopy. RESULTS: Mucous layer thickness was significantly greater in eyes treated with PEG/PG/HP-guar products compared with those treated with 0.1% hyaluronate sodium, 0.5% carboxymethylcellulose, or phosphate-buffered saline (all P values < 0.001). There were no significant differences in mucous layer thickness between PEG/PG/HP-guar products and PEG/PG/HP-guar with Polyquad or in the long- and short-term exposure animals. CONCLUSIONS: This study demonstrates that even a short exposure to PEG/PG/HP-guar tear product increased precorneal mucous layer thickness. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1430~1435 | - |
dc.relation.isPartOf | CORNEA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carboxymethylcellulose Sodium/toxicity | - |
dc.subject.MESH | Cornea/drug effects* | - |
dc.subject.MESH | Cornea/ultrastructure | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Hyaluronic Acid/toxicity | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Mucous Membrane/drug effects | - |
dc.subject.MESH | Mucous Membrane/ultrastructure | - |
dc.subject.MESH | Ophthalmic Solutions/toxicity* | - |
dc.subject.MESH | Polyethylene Glycols/toxicity* | - |
dc.subject.MESH | Polysaccharides/toxicity* | - |
dc.subject.MESH | Rabbits | - |
dc.title | The impact of artificial tears containing hydroxypropyl guar on mucous layer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Sang-Woong Moon | - |
dc.contributor.googleauthor | Je-Hyung Hwang | - |
dc.contributor.googleauthor | So-Hyang Chung | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.identifier.doi | 10.1097/ICO.0b013e3181ca636b | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01245 | - |
dc.relation.journalcode | J00648 | - |
dc.identifier.eissn | 1536-4798 | - |
dc.identifier.pmid | 20805744 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-201012000-00016&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Nam, Kee Hyun | - |
dc.citation.volume | 29 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1430 | - |
dc.citation.endPage | 1435 | - |
dc.identifier.bibliographicCitation | CORNEA, Vol.29(12) : 1430-1435, 2010 | - |
dc.identifier.rimsid | 35117 | - |
dc.type.rims | ART | - |
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