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The impact of artificial tears containing hydroxypropyl guar on mucous layer

 Sang-Woong Moon  ;  Je-Hyung Hwang  ;  So-Hyang Chung  ;  Kee-Hyun Nam 
 CORNEA, Vol.29(12) : 1430-1435, 2010 
Journal Title
Issue Date
Animals ; Carboxymethylcellulose Sodium/toxicity ; Cornea/drug effects* ; Cornea/ultrastructure ; Drug Combinations ; Hyaluronic Acid/toxicity ; Male ; Microscopy, Electron, Transmission ; Mucous Membrane/drug effects ; Mucous Membrane/ultrastructure ; Ophthalmic Solutions/toxicity* ; Polyethylene Glycols/toxicity* ; Polysaccharides/toxicity* ; Rabbits
PURPOSE: The aim of this study was to investigate the effect of lubricant eyedrops containing propylene glycol 400 (PEG) and polyethylene glycol (PG) with hydroxypropyl guar (HP-guar) as a gelling agent on the precorneal mucous layer in vivo.

METHODS: Sixteen New Zealand white rabbits were randomly assigned to 1 of 4 groups. All rabbits received PEG/PG/HP-guar tear products in the right eye. PEG/PG/HP-guar with Polyquad, 0.1% hyaluronate sodium, 0.5% carboxymethylcellulose, or phosphate-buffered saline was placed in the left eyes of animals in each group. All eyedrops were used 4 times a day for 7 days. An additional 8 rabbits were randomly assigned to 1 of 2 groups. One group received PEG/PG/HP-guar products 4 times a day for 7 days (long-term exposure group), and the other group received PEG/PG/HP-guar products 3 times at 5-minute intervals (short-term exposure group). Fifteen minutes after the last drop was administered, each cornea was immediately excised and mucous layer thickness measured by transmission electron microscopy.

RESULTS: Mucous layer thickness was significantly greater in eyes treated with PEG/PG/HP-guar products compared with those treated with 0.1% hyaluronate sodium, 0.5% carboxymethylcellulose, or phosphate-buffered saline (all P values < 0.001). There were no significant differences in mucous layer thickness between PEG/PG/HP-guar products and PEG/PG/HP-guar with Polyquad or in the long- and short-term exposure animals.

CONCLUSIONS: This study demonstrates that even a short exposure to PEG/PG/HP-guar tear product increased precorneal mucous layer thickness.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
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