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Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?

DC Field Value Language
dc.contributor.author이상길-
dc.date.accessioned2015-04-23T17:41:39Z-
dc.date.available2015-04-23T17:41:39Z-
dc.date.issued2010-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102950-
dc.description.abstractSynthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited, among many applications, for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modular device based on a hammerhead ribozyme and successfully tested its ability to control the proliferation of mammalian T lymphocytes. Like all exciting research, this work raises a lot of significant questions. How quickly will such knowledge be translated into clinical practice? How efficient will this system be in human clinical trials involving adaptive T-cell therapy? We discuss the possible advantages of using such new technologies for specific therapeutic applications.-
dc.description.statementOfResponsibilityopen-
dc.format.extent77-
dc.relation.isPartOfGENOME MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleGenetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorGeorge A Calin-
dc.identifier.doi10.1186/gm198-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02812-
dc.relation.journalcodeJ00938-
dc.identifier.eissn1756-994X-
dc.identifier.pmid20959026-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.citation.volume2-
dc.citation.number10-
dc.citation.startPage77-
dc.identifier.bibliographicCitationGENOME MEDICINE, Vol.2(10) : 77, 2010-
dc.identifier.rimsid35112-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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