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Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2015-04-23T17:41:39Z | - |
dc.date.available | 2015-04-23T17:41:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102950 | - |
dc.description.abstract | Synthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited, among many applications, for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modular device based on a hammerhead ribozyme and successfully tested its ability to control the proliferation of mammalian T lymphocytes. Like all exciting research, this work raises a lot of significant questions. How quickly will such knowledge be translated into clinical practice? How efficient will this system be in human clinical trials involving adaptive T-cell therapy? We discuss the possible advantages of using such new technologies for specific therapeutic applications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 77 | - |
dc.relation.isPartOf | GENOME MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | George A Calin | - |
dc.identifier.doi | 10.1186/gm198 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02812 | - |
dc.relation.journalcode | J00938 | - |
dc.identifier.eissn | 1756-994X | - |
dc.identifier.pmid | 20959026 | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.citation.volume | 2 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 77 | - |
dc.identifier.bibliographicCitation | GENOME MEDICINE, Vol.2(10) : 77, 2010 | - |
dc.identifier.rimsid | 35112 | - |
dc.type.rims | ART | - |
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