Cited 8 times in
TNBS 유도 대장염에서의 Microarray 분석과 Saccharomyces boulardii의 역할에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2015-04-23T17:41:37Z | - |
dc.date.available | 2015-04-23T17:41:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102949 | - |
dc.description.abstract | BACKGROUND/AIMS: Saccharomyces boulardii has been reported to be beneficial in the treatment of inflammatory bowel disease. The aim of this work was to evaluate the effect of S. boulardii in a mice model of 2,4,6-trinitrobencene sulfonic acid (TNBS) induced colitis and analyze the expression of genes in S. boulardii treated mice by microarray. METHODS: BALB/c mice received TNBS or TNBS and S. boulardii treatment for 4 days. Microarray was performed on total mRNA form colon, and histologic evaluation was also performed. RESULTS: In mice treated with S. boulardii, the histological appearance and mortality rate were significantly restored compared with rats receiving only TNBS. Among 330 genes which were altered by both S. boulardii and TNBS (>2 folds), 193 genes were down-regulated by S. boulardii in microarray. Most of genes which were down-regulated by S. bouardii were functionally classified as inflammatory and immune response related genes. CONCLUSIONS: S. boulardii may reduce colonic inflammation along with regulation of inflammatory and immune responsive genes in TNBS-induced colitis | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~45 | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Colitis/chemically induced | - |
dc.subject.MESH | Colitis/genetics | - |
dc.subject.MESH | Colitis/therapy* | - |
dc.subject.MESH | Colon/metabolism | - |
dc.subject.MESH | Colon/pathology | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Probiotics* | - |
dc.subject.MESH | Saccharomyces* | - |
dc.subject.MESH | Trinitrobenzenesulfonic Acid | - |
dc.title | TNBS 유도 대장염에서의 Microarray 분석과 Saccharomyces boulardii의 역할에 관한 연구 | - |
dc.title.alternative | Saccharomyces boulardii Reduced Intestinal Inflammation in Mice Model of 2,4,6-trinitrobencene Sulfonic Acid Induced Colitis: Based on Microarray | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 이상길 | - |
dc.contributor.googleauthor | 김효종 | - |
dc.contributor.googleauthor | 지성길 | - |
dc.identifier.doi | 10.4166/kjg.2010.55.1.33 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02812 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.identifier.pmid | 20098065 | - |
dc.subject.keyword | Saccharomyces boulardii | - |
dc.subject.keyword | Microarray | - |
dc.subject.keyword | TNBS colitis | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.55(1) : 33-45, 2010 | - |
dc.identifier.rimsid | 35111 | - |
dc.type.rims | ART | - |
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