Cited 7 times in
In Vitro Adenosine Triphosphate Based Chemotherapy Response Assay in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 형우진 | - |
dc.date.accessioned | 2015-04-23T17:40:26Z | - |
dc.date.available | 2015-04-23T17:40:26Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 2093-582X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102911 | - |
dc.description.abstract | PURPOSE: The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. MATERIALS AND METHODS: A total of 243 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2010. We evaluated the effectiveness of the ATP-CRA assay in determining the chemosensitivity of gastric cancer specimens using eleven chemotherapeutic agents - etoposide, doxorubicin, epirubicin, mytomicin, 5-fluorouracil, oxaliplatin, irinotecan, docetaxel, paclitaxel, methotraxate, and cisplatin - for chemosensitivity studies using ATP-CRA. We assessed the failure rate, the cell death rate, and the chemosensitivity index. RESULTS: The failure rate of ATP-CRA was 1.6% (4/243). The mean coefficient of variation for triplicate ATP measurements was 6.5%. Etoposide showed the highest cell death rate (35.9%) while methotrexate showed the lowest (16.6%). The most active chemotherapeutic agent was etoposide, which most frequently ranked highest in the chemosensitivity test: 31.9% (51/160). Oxaliplatin was more active against early gastric cancers than advanced gastric cancers, whereas docetaxel was more active against advanced cancers. The lymph node negative group showed a significantly higher cell death rate than the lymph node positive group when treated with doxorubicin, epirubicin, and mitomycin. CONCLUSIONS: ATP-CRA is a stable and clinically applicable in vitro chemosensitivity test with a low failure rate. The clinical usefulness of ATP-CRA should be evaluated by prospective studies comparing the regimen guided by ATP-CRA with an empirical regimen | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 155~161 | - |
dc.relation.isPartOf | JOURNAL OF GASTRIC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | In Vitro Adenosine Triphosphate Based Chemotherapy Response Assay in Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seulkee Park | - |
dc.contributor.googleauthor | Yanghee Woo | - |
dc.contributor.googleauthor | Hogeun Kim | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Sungho Choi | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.identifier.doi | 10.5230/jgc.2010.10.4.155 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J01415 | - |
dc.identifier.eissn | 2093-5641 | - |
dc.identifier.pmid | 22076180 | - |
dc.subject.keyword | ATP based chemoresponse | - |
dc.subject.keyword | Chemosensitivity assay | - |
dc.subject.keyword | Stomach neoplasms | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 161 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTRIC CANCER, Vol.10(4) : 155-161, 2010 | - |
dc.identifier.rimsid | 35087 | - |
dc.type.rims | ART | - |
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