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Comparison of the affinity column-mediated immunoassay and microparticle enzyme immunoassay methods as a tacrolimus concentration assay in the early period after liver transplantation

DC Field Value Language
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author허규하-
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author정인경-
dc.contributor.author주동진-
dc.date.accessioned2015-04-23T17:40:18Z-
dc.date.available2015-04-23T17:40:18Z-
dc.date.issued2010-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102907-
dc.description.abstractOBJECTIVE: We compared the results of 2 immunoassay systems (affinity column-mediated immunoassay [ACMIA] and microparticle enzyme immunoassay [MEIA]), regarding hematologic and biochemical values at 2 weeks after liver transplantation. METHODS: We obtained 256 blood samples from 35 patients, at 2 weeks after liver transplantation, excluding those from patients who were treated with interacting medications or renal replacement therapy. We also excluded the early mortality cases within 2 weeks of liver transplantation. A Dimension RxL HM with the tacrolimus Flex reagent cartilage was used for the ACMIA and the IMx tacrolimus II for the MEIA method. RESULTS: The tacrolimus concentrations measured by the ACMIA method correlated closely with those measured by the MEIA method (r = 0.953). However, the weighted concordance correlation coefficient for the repeated-measurement design was 0.74 (95% confidence interval, 0.66-0.85). The discrepancies in the tacrolimus level between the 2 methods was large among samples with low tacrolimus concentrations especially <5 ng/mL. When the difference ratio of the 2 methods ([ACMIA - MEIA]/ACMIA) was analyzed with a linear mixed-effects model to identify significant laboratory findings, there were no significant differences based on hematocrit, renal function, or hepatic function. However, the serum potassium level correlated with the difference ratio of the 2 methods (estimated slope, 10.173; P = .02). CONCLUSIONS: Both the ACMIA and the MEIA methods are precise; however, the ACMIA method has the advantage of fewer pretreatment procedures. In the early liver transplant period, however, there was a difference between the serum tacrolimus concentrations measured by the 2 methods, especially at a low drug concentrations.-
dc.description.statementOfResponsibilityopen-
dc.format.extent4137~4140-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChromatography, Affinity/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques/methods*-
dc.subject.MESHImmunosuppressive Agents/blood*-
dc.subject.MESHLiver Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHTacrolimus/blood*-
dc.titleComparison of the affinity column-mediated immunoassay and microparticle enzyme immunoassay methods as a tacrolimus concentration assay in the early period after liver transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biostatistics (의학통계학)-
dc.contributor.googleauthorD.J. Joo-
dc.contributor.googleauthorI. Jung-
dc.contributor.googleauthorM.S. Kim-
dc.contributor.googleauthorK.H. Huh-
dc.contributor.googleauthorH. Kim-
dc.contributor.googleauthorJ.S. Choi-
dc.contributor.googleauthorG.H. Choi-
dc.contributor.googleauthorS.I. Kim-
dc.identifier.doi10.1016/j.transproceed.2010.09.088-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA04344-
dc.contributor.localIdA00649-
dc.contributor.localIdA03693-
dc.contributor.localIdA03948-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid21168645-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134510015083-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameJung, In Kyung-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorJung, In Kyung-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.citation.volume42-
dc.citation.number10-
dc.citation.startPage4137-
dc.citation.endPage4140-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.42(10) : 4137-4140, 2010-
dc.identifier.rimsid35085-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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