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Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis.

Authors
 Kim, Ja Kyung  ;  Park, Young Nyun  ;  Kim, Jin Seok  ;  Park, Mi-Suk  ;  Paik, Yong Han  ;  Seok, Jae-Yeon  ;  Chung, Yong Eun  ;  Kim, Hyun Ok  ;  Kim, Kyung Sik  ;  Ahn, Sang Hoon  ;  Kim, Do Young  ;  Kim, Myeong-Jin  ;  Lee, Kwan Sik  ;  Chon, Chae Yoon  ;  Kim, Soo Jeong  ;  Terai, Shuji  ;  Sakaida, Isao  ;  Han, Kwang-Hyub 
Citation
 CELL TRANSPLANTATION, Vol.19(10) : 1237-1246, 2010 
Journal Title
 CELL TRANSPLANTATION 
ISSN
 0963-6897 
Issue Date
2010
MeSH
Adult ; Bone Marrow Cells/cytology* ; Bone Marrow Transplantation* ; Female ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/pathology ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Liver Cirrhosis/surgery* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Quality of Life ; Severity of Illness Index ; Stem Cells/cytology ; Surveys and Questionnaires ; Time Factors ; Transplantation, Autologous
Keywords
Adult bone marrow stem cell ; Autologous bone marrow transplantation ; Liver cirrhosis ; Liver regeneration ; Progenitor cell
Abstract
Several clinical trials of bone marrow cell infusion in patients with liver cirrhosis (LC) have shown clinical improvement, despite conflicting results from animal models. We investigated serial pathological features and the clinical impact after autologous bone marrow infusion (ABMI) in patients with advanced LC. Ten patients with advanced LC due to chronic hepatitis B virus infection underwent ABMI. Serological tests, MRI, and liver biopsies were performed, and quality of life was assessed by a questionnaire. Median serum albumin and hemoglobin levels increased significantly after ABMI. All patients showed an improvement in quality of life, with no serious adverse events. Liver volume, measured by MRI, increased in 80% of the patients, and ascites decreased after ABMI. Child-Pugh scores were also significantly improved at 6 months after ABMI. In the serially biopsied livers, a gradually increasing activation of the hepatic progenitor cell (HPC) compartment, including HPC activation (ductular reaction) and HPC differentiation (intermediate hepatocyte), reached a peak after 3 months, with continued proliferation of hepatocytes, and returned to baseline levels after 6 months. There was no significant change in grade or stage of liver fibrosis or stellate cell activation after ABMI. ABMI is suggested to improve liver function and to activate the progenitor cell compartment. Although clinical improvement was sustained for more than 6 months, histological changes in the liver returned to baseline 6 months after ABMI. Further comparative studies are warranted.
Full Text
http://www.ingentaconnect.com/content/cog/ct/2010/00000019/00000010/art00003
DOI
10.3727/096368910X506863
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Do Young(김도영)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Paik, Yong Han(백용한)
Seok, Jae Yeon(석재연)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102757
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