Cited 40 times in
c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma
DC Field | Value | Language |
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dc.contributor.author | 최은창 | - |
dc.date.accessioned | 2015-04-23T17:32:49Z | - |
dc.date.available | 2015-04-23T17:32:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102675 | - |
dc.description.abstract | BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1655~1664 | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatocyte Growth Factor/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-met/metabolism* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Tongue Neoplasms/metabolism* | - |
dc.subject.MESH | Tongue Neoplasms/mortality | - |
dc.subject.MESH | Tongue Neoplasms/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Chul-Ho Kim | - |
dc.contributor.googleauthor | Yoon Woo Koh | - |
dc.contributor.googleauthor | Jae Ho Han | - |
dc.contributor.googleauthor | Jae Wook Kim | - |
dc.contributor.googleauthor | Jin Seok Lee | - |
dc.contributor.googleauthor | Seung Jae Baek | - |
dc.contributor.googleauthor | Hye Sook Hwang | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.identifier.doi | 10.1002/hed.21383 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04161 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 20848408 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hed.21383/abstract | - |
dc.contributor.alternativeName | Choi, Eun Chang | - |
dc.contributor.affiliatedAuthor | Choi, Eun Chang | - |
dc.citation.volume | 32 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1655 | - |
dc.citation.endPage | 1664 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.32(12) : 1655-1664, 2010 | - |
dc.identifier.rimsid | 56425 | - |
dc.type.rims | ART | - |
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