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c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma

Authors
 Chul-Ho Kim  ;  Yoon Woo Koh  ;  Jae Ho Han  ;  Jae Wook Kim  ;  Jin Seok Lee  ;  Seung Jae Baek  ;  Hye Sook Hwang  ;  Eun Chang Choi 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.32(12) : 1655-1664, 2010 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2010
MeSH
Adult ; Aged ; Blotting, Western ; Carcinoma, Squamous Cell/metabolism* ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Disease-Free Survival ; Female ; Hepatocyte Growth Factor/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Proto-Oncogene Proteins c-met/metabolism* ; Survival Analysis ; Tongue Neoplasms/metabolism* ; Tongue Neoplasms/mortality ; Tongue Neoplasms/pathology ; Young Adult
Abstract
BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.21383/abstract
DOI
10.1002/hed.21383
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102675
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