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Thiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages

Authors
 Rayun Choi  ;  Jaemoon Yang  ;  Jihye Choi  ;  Eun-Kyung Lim  ;  Eunjung Kim  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 LANGMUIR, Vol.26(22) : 17520-17527, 2010 
Journal Title
LANGMUIR
ISSN
 0743-7463 
Issue Date
2010
MeSH
Ablation Techniques/methods* ; Animals ; Biological Transport ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dextrans/chemistry* ; Dextrans/metabolism ; Dextrans/pharmacology* ; Dextrans/toxicity ; Gold/chemistry* ; Inflammation/pathology ; Inflammation/surgery ; Infrared Rays ; Macrophages/drug effects* ; Macrophages/pathology ; Macrophages/radiation effects ; Molecular Weight ; Nanotubes/chemistry* ; Polyethylene Glycols/chemistry ; Temperature
Abstract
Thiolated dextran-coated gold nanorods (DEX-GNRs) were synthesized for targeted delivery to inflammatory macrophages and their photothermal ablation under near-infrared (NIR) light irradiation. Successful synthesis of DEX-GNRs was achieved using thiolated dextran, generated by applying mercaptopropionic acid to transform a hydroxyl group of dextran into a thiol group which has strong binding affinity with surfaces of GNRs. We confirmed both the existence of a thiol group in the functionalized dextran using Ellman's reagent in a thiol group assay and the characteristic band of DEX-GNRs using FT-IR spectrum. Furthermore, a cellular uptake study revealed that dextran showed a superior ability to bind the GNRs surface against macrophages compared to those of PEGylated GNRs with various molecular weights of polyethyleneglycol (PEG). Consequently, an in vitro photothermal irradiation experiment using NIR light indicated that DEX-GNRs exhibited a significant cell-killing efficacy, even with a lower concentration of Au and a low-power light source
Files in This Item:
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DOI
10.1021/la1029728
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102670
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