Cited 4 times in
Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica
DC Field | Value | Language |
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dc.contributor.author | 신명헌 | - |
dc.contributor.author | 이영아 | - |
dc.date.accessioned | 2015-04-23T17:30:09Z | - |
dc.date.available | 2015-04-23T17:30:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102587 | - |
dc.description.abstract | Tyrosine kinases are one of the most important regulators for intracellular signal transduction related to inflammatory responses. However, there are no reports describing the effects of tyrosine kinases on neutrophil apoptosis induced by Entamoeba histolytica. In this study, isolated human neutrophils from peripheral blood were incubated with live trophozoites in the presence or absence of tyrosine kinase inhibitors. Entamoeba-induced receptor shedding of CD16 and PS externalization in neutrophils were inhibited by pre-incubation of neutrophils with the broad-spectrum tyrosine kinase inhibitor genistein or the Src family kinase inhibitor PP2. Entamoeba-induced ROS production was also inhibited by genistein or PP2. Moreover, genistein and PP2 blocked the phosphorylation of ERK and p38 MAPK in neutrophils induced by E. histolytica. These results suggest that Src tyrosine kinases may participate in the signaling event for ROS-dependent activation of MAPKs during neutrophil apoptosis induced by E. histolytica | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 285~290 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Entamoeba histolytica/immunology* | - |
dc.subject.MESH | Entamoeba histolytica/pathogenicity* | - |
dc.subject.MESH | GPI-Linked Proteins/metabolism | - |
dc.subject.MESH | Genistein/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neutrophils/immunology* | - |
dc.subject.MESH | Protein Kinase Inhibitors/metabolism | - |
dc.subject.MESH | Pyrimidines/metabolism | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Receptors, IgG/metabolism | - |
dc.subject.MESH | src-Family Kinases/antagonists & inhibitors | - |
dc.subject.MESH | src-Family Kinases/metabolism* | - |
dc.title | Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Seobo Sim | - |
dc.contributor.googleauthor | Jae-Ran Yu | - |
dc.contributor.googleauthor | Young Ah Lee | - |
dc.contributor.googleauthor | Myeong Heon Shin | - |
dc.identifier.doi | 10.3347/kjp.2010.48.4.285 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02099 | - |
dc.contributor.localId | A02959 | - |
dc.relation.journalcode | J01957 | - |
dc.identifier.eissn | 1738-0006 | - |
dc.identifier.pmid | 21234229 | - |
dc.subject.keyword | Entamoeba histolytica | - |
dc.subject.keyword | Src tyrosine kinase | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | neutrophil | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.contributor.alternativeName | Lee, Young Ah | - |
dc.contributor.affiliatedAuthor | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | Lee, Young Ah | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 285 | - |
dc.citation.endPage | 290 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, Vol.48(4) : 285-290, 2010 | - |
dc.identifier.rimsid | 55312 | - |
dc.type.rims | ART | - |
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