Inhibitory Effects of Neo Muscat Grape Vine Extracts on Melanin Biosynthesis

Abstract

Neo Muscat grape vine extracts significantly inhibited melanin production in melanocyte stimulating hormone-stimulated B16 cells. They also exhibited tyrosinase inhibitory activity and reduced the levels of intra-cellular tyrosinase. Moreover, when the extracts were treated with UV B-induced hyper-pigmented brown guinea pig skin, depigmenting activity was observed, but with no visible edema. These results indicate that the vine extracts of Neo Muscat grapes might prove useful as a skin depigmenting agent