Cited 9 times in
Adiponectin gene polymorphisms are associated with long-chain ω3-polyunsaturated fatty acids in serum phospholipids in nondiabetic Koreans
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 이상학 | - |
dc.date.accessioned | 2015-04-23T17:27:05Z | - |
dc.date.available | 2015-04-23T17:27:05Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102489 | - |
dc.description.abstract | CONTEXT: Hypoadiponectinemia is caused by interactions between genetic and environmental factors, including the quality of dietary fats. OBJECTIVE: We investigated the association of single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) with dietary fat intake or fatty acid (FA) composition in serum phospholipids, plasma adiponectin, and insulin resistance. METHODS: Nondiabetic subjects (n = 1194) were genotyped for three ADIPOQ SNPs (-11377C>G; 45T>G; 276G>T) after screening of eight sites. Dietary fat intake, FA composition in serum phospholipids, adiponectin, and homeostasis model assessment of insulin resistance (HOMA-IR) were also measured. RESULTS: The 276G carriers (n = 1082) showed lower high-density lipoprotein cholesterol (P = 0.024) and adiponectin (P < 0.001) but higher glucose (P = 0.015) and HOMA-IR (P = 0.005) than 276T/T subjects (n = 112). No associations were found in other SNPs. After adjusted for age, sex, body mass index, and the proportion of 18:2ω6 and 18:3ω3 (biomarkers of long term essential FA intake), the 276G carriers showed lower proportions of total ω3FA (P = 0.026), 20:5ω3 (P = 0.021), and 22:5ω3 (P = 0.024) in serum phospholipids. Among FAs in serum phospholipids, 18:2ω6 highly correlated with ω3-polyunsaturated FA (PUFA) intake (r = 0.260, P < 0.001) and adiponectin (r = 0.150, P < 0.001). The 276G carriers with a higher proportion of 18:2ω6 (≥12.5%) exhibited more pronounced characteristics, i.e. lower adiponectin (P < 0.001), lower high-density lipoprotein cholesterol (P = 0.004), higher HOMA-IR (P = 0.013), and lower long-chain ω3PUFAs (20:5ω3, 22:5ω3, and 22:6ω3, P < 0.001). Additionally, the effect of 276G>T on the relationship between adiponectin and HOMA-IR was modified by 18:2ω6 proportion. CONCLUSION: ADIPOQ 276G is associated with reduced proportion of long-chain ω3PUFAs in serum phospholipids in nondiabetic Koreans | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e347~e351 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood | - |
dc.subject.MESH | Adiponectin/genetics* | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Dietary Fats | - |
dc.subject.MESH | Fatty Acids, Omega-3/blood* | - |
dc.subject.MESH | Fatty Acids, Omega-3/genetics | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Association Studies | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance/genetics | - |
dc.subject.MESH | Phospholipids/blood* | - |
dc.subject.MESH | Phospholipids/genetics | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.title | Adiponectin gene polymorphisms are associated with long-chain ω3-polyunsaturated fatty acids in serum phospholipids in nondiabetic Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Bumsik Kim | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Jose M. Ordovas | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1210/jc.2010-0391 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 20685864 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.citation.volume | 95 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 347 | - |
dc.citation.endPage | 351 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.95(11) : 347-351, 2010 | - |
dc.identifier.rimsid | 49790 | - |
dc.type.rims | ART | - |
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