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Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김남희 | - |
dc.contributor.author | 김현실 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 차소영 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-04-23T17:25:39Z | - |
dc.date.available | 2015-04-23T17:25:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102443 | - |
dc.description.abstract | Protein O-phosphorylation often occurs reciprocally with O-GlcNAc modification and represents a regulatory principle for proteins. O-phosphorylation of serine by glycogen synthase kinase-3β on Snail1, a transcriptional repressor of E-cadherin and a key regulator of the epithelial-mesenchymal transition (EMT) programme, results in its proteasomal degradation. We show that by suppressing O-phosphorylation-mediated degradation, O-GlcNAc at serine112 stabilizes Snail1 and thus increases its repressor function, which in turn attenuates E-cadherin mRNA expression. Hyperglycaemic condition enhances O-GlcNAc modification and initiates EMT by transcriptional suppression of E-cadherin through Snail1. Thus, dynamic reciprocal O-phosphorylation and O-GlcNAc modification of Snail1 constitute a molecular link between cellular glucose metabolism and the control of EMT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3787~3796 | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylglucosamine/metabolism* | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Cadherins/genetics | - |
dc.subject.MESH | Cadherins/metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Glucose/metabolism | - |
dc.subject.MESH | HEK293 Cells | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperglycemia/metabolism* | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Protein Stability | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Serine/metabolism | - |
dc.subject.MESH | Snail Family Transcription Factors | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.title | Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Oral Cancer Research Institute (구강종양연구소) | - |
dc.contributor.googleauthor | Sang Yoon Park | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.contributor.googleauthor | Nam Hee Kim | - |
dc.contributor.googleauthor | Suena Ji | - |
dc.contributor.googleauthor | So Young Cha | - |
dc.contributor.googleauthor | Jeong Gu Kang | - |
dc.contributor.googleauthor | Ichiro Ota | - |
dc.contributor.googleauthor | Keiji Shimada | - |
dc.contributor.googleauthor | Noboru Konishi | - |
dc.contributor.googleauthor | Hyung Wook Nam | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Won Ho Yang | - |
dc.contributor.googleauthor | Ju¨ rgen Roth | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Jin Won Cho | - |
dc.identifier.doi | 10.1038/ emboj.2010.254 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00360 | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03997 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00763 | - |
dc.identifier.eissn | 1460-2075 | - |
dc.identifier.pmid | 20959806 | - |
dc.contributor.alternativeName | Kim, Nam Hee | - |
dc.contributor.alternativeName | Kim, Hyun Sil | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.alternativeName | Cha, So Young | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Nam Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Sil | - |
dc.contributor.affiliatedAuthor | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | Cha, So Young | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.citation.volume | 29 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 3787 | - |
dc.citation.endPage | 3796 | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, Vol.29(22) : 3787-3796, 2010 | - |
dc.identifier.rimsid | 57333 | - |
dc.type.rims | ART | - |
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