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TrkC plays an essential role in breast tumor growth and metastasis

DC Field Value Language
dc.contributor.author정준-
dc.date.accessioned2015-04-23T17:25:14Z-
dc.date.available2015-04-23T17:25:14Z-
dc.date.issued2010-
dc.identifier.issn0143-3334-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102429-
dc.description.abstractTropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis. Ectopic expression of TrkC in non-malignant mammary epithelial cells suppressed anoikis, which correlated with activation of the Ras-mitogen-activated protein kinase and phosphatidylinositol-3-OH kinase (PI3K)/Akt pathways, and reduced expression of the metastatic regulator Twist. Furthermore, suppression of TrkC expression in highly metastatic mammary carcinoma cells inhibited their growth in vitro, as well as their ability to metastasize from the mammary gland to the lung in vivo. These results have identified TrkC as a critical regulator of breast cancer cell growth and metastasis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1939~1947-
dc.relation.isPartOfCARCINOGENESIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHBreast Neoplasms/genetics-
dc.subject.MESHBreast Neoplasms/metabolism-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCarcinoma, Ductal, Breast/genetics-
dc.subject.MESHCarcinoma, Ductal, Breast/metabolism-
dc.subject.MESHCarcinoma, Ductal, Breast/secondary*-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCell Movement-
dc.subject.MESHCell Proliferation-
dc.subject.MESHFemale-
dc.subject.MESHFluorescent Antibody Technique-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHImmunoprecipitation-
dc.subject.MESHLung Neoplasms/genetics-
dc.subject.MESHLung Neoplasms/metabolism-
dc.subject.MESHLung Neoplasms/secondary*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Small Interfering/pharmacology-
dc.subject.MESHReceptor, trkC/physiology*-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.titleTrkC plays an essential role in breast tumor growth and metastasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorWook Jin-
dc.contributor.googleauthorGyoung Mi Kim-
dc.contributor.googleauthorMin Soo Kim-
dc.contributor.googleauthorMi Hee Lim-
dc.contributor.googleauthorChohee Yun-
dc.contributor.googleauthorJoon Jeong-
dc.contributor.googleauthorJeong-Seok Nam-
dc.contributor.googleauthorSeong-Jin Kim-
dc.identifier.doi10.1093/carcin/bgq180-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03727-
dc.relation.journalcodeJ00456-
dc.identifier.eissn1460-2180-
dc.identifier.pmid20802235-
dc.subject.keywordbreast neoplasms-
dc.subject.keywordneoplasm metastasis-
dc.subject.keywordneurotrophic tyrosine kinase receptor type 3-
dc.subject.keywordtumor growth-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.affiliatedAuthorJeong, Joon-
dc.citation.volume31-
dc.citation.number11-
dc.citation.startPage1939-
dc.citation.endPage1947-
dc.identifier.bibliographicCitationCARCINOGENESIS, Vol.31(11) : 1939-1947, 2010-
dc.identifier.rimsid57325-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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