Cited 17 times in
Determination of lamotrigine in human serum by high-performance liquid chromatography–tandem mass spectrometry.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오헌 | - |
dc.contributor.author | 김정호 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 이운형 | - |
dc.contributor.author | 허경 | - |
dc.date.accessioned | 2015-04-23T17:22:53Z | - |
dc.date.available | 2015-04-23T17:22:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102352 | - |
dc.description.abstract | A rapid and sensitive liquid chromatography–tandem mass spectrometry method was developed and validated for quantification of lamotrigine in human serum. After a simple protein precipitation using acetonitrile, the analytes were separated on a Shideido 150 mm × 2.0 mm, 5 μm Capcell Pak C18 MG column using 70% acetonitrileas mobile phase at a flow rate of 200 μl/min. Lamotrigine was eluted at 1.98 min, ionized using electrospray ionization source, and then detected by multiple reaction monitoring mode. The precursor to product ion transitions of m/z 256.1–109.0 was used to quantify. The analytical measurement range is from 0.1 to 20 μg/ml and the upper clinical reportable range is chosen to be 100 μg/ml. The method was successfully employed in a clinical application | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 717~720 | - |
dc.relation.isPartOf | NEUROLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anticonvulsants/blood | - |
dc.subject.MESH | Anticonvulsants/pharmacokinetics | - |
dc.subject.MESH | Antimanic Agents/blood | - |
dc.subject.MESH | Antimanic Agents/pharmacokinetics | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods | - |
dc.subject.MESH | Drug Monitoring/methods | - |
dc.subject.MESH | Epilepsy/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tandem Mass Spectrometry/methods* | - |
dc.subject.MESH | Triazines/blood* | - |
dc.subject.MESH | Triazines/pharmacokinetics | - |
dc.title | Determination of lamotrigine in human serum by high-performance liquid chromatography–tandem mass spectrometry. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Woonhyoung Lee | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.contributor.googleauthor | Oh Hun Kwon | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.contributor.googleauthor | Kyoung Heo | - |
dc.identifier.doi | 10.1007/s10072-010-0257-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00237 | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A02997 | - |
dc.contributor.localId | A04341 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J02338 | - |
dc.identifier.eissn | 1590-3478 | - |
dc.identifier.pmid | 20390433 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10072-010-0257-x | - |
dc.subject.keyword | Lamotrigine | - |
dc.subject.keyword | Tandem mass spectrometry | - |
dc.subject.keyword | High pressure liquid chromatography | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Drug monitoring | - |
dc.contributor.alternativeName | Kwon, Oh Hun | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Lee, Woon Hyoung | - |
dc.contributor.alternativeName | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Kwon, Oh Hun | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Lee, Woon Hyoung | - |
dc.contributor.affiliatedAuthor | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.citation.volume | 31 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 717 | - |
dc.citation.endPage | 720 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL SCIENCES, Vol.31(6) : 717-720, 2010 | - |
dc.identifier.rimsid | 40878 | - |
dc.type.rims | ART | - |
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