596 482

Cited 67 times in

Association of stress with symptoms of atopic dermatitis

DC Field Value Language
dc.contributor.author박창욱-
dc.contributor.author오상호-
dc.contributor.author이광훈-
dc.date.accessioned2015-04-23T17:20:00Z-
dc.date.available2015-04-23T17:20:00Z-
dc.date.issued2010-
dc.identifier.issn0001-5555-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102262-
dc.description.abstractPsychological stress and atopic dermatitis (AD) symptoms appear to form a vicious cycle. This study compared the degree of stress and impairment of dermatology life quality between patients with AD and healthy controls, and examined for neuropeptides and neurotrophins associated with stress in AD. Questionnaires, comprising five tests evaluating depression, anxiety, interaction anxiousness, private body consciousness, and dermatology life quality, were examined in age- and sex-matched patients with AD (n = 28) and healthy controls (n = 28). Immunohistochemical staining of nerve growth factor, substance P, corticotrophin-releasing factor receptor and neuropeptide Y was performed in the AD-involved and normal skin. Patients with AD showed high scores on all of the questionnaires, including Beck Depression Inventory, state anxiety, trait anxiety, Interaction Anxiousness Scale, Private Body Consciousness subscale, and Dermatology Life Quality Index. All of the parameters, except for Beck Depression Inventory, showed higher values in AD than healthy controls (p < 0.001). Statistically significant correlations were observed between each psychological parameter and Dermatology Life Quality Index. Among the clinical parameters, only pruritus was positively correlated with state anxiety (R = 0.573, p < 0.05) and trait anxiety (R = 0.525, p < 0.05). The Eczema Area and Severity Index score did not show any significant correlations with psychological parameters. Nerve growth factor-reactive cells were observed more abundantly and intensely in both epidermis and dermis of AD involved skin (n = 4) than in healthy controls (n = 3) (p = 0.022 and 0.029, respectively). Also, the number and intensity of neuropeptide Y-positive cells was significantly greater in the entire epidermis of patients with AD than in healthy controls (n = 3) (p = 0.029 and 0.026, respectively). We conclude that anxiety may be associated with the induction of pruritus through neuro-peptide Y and nerve growth factor-
dc.description.statementOfResponsibilityopen-
dc.format.extent582~588-
dc.relation.isPartOfACTA DERMATO-VENEREOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAnxiety/complications*-
dc.subject.MESHAnxiety/diagnosis-
dc.subject.MESHAnxiety/metabolism-
dc.subject.MESHBiopsy-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChild-
dc.subject.MESHDepression/complications-
dc.subject.MESHDermatitis, Atopic/diagnosis-
dc.subject.MESHDermatitis, Atopic/metabolism-
dc.subject.MESHDermatitis, Atopic/psychology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNerve Growth Factor/analysis-
dc.subject.MESHNeuropeptide Y/analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHPruritus/metabolism-
dc.subject.MESHPruritus/psychology-
dc.subject.MESHQuality of Life-
dc.subject.MESHReceptors, Corticotropin-Releasing Hormone/analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSkin/chemistry*-
dc.subject.MESHStress, Psychological/complications*-
dc.subject.MESHStress, Psychological/diagnosis-
dc.subject.MESHStress, Psychological/metabolism-
dc.subject.MESHSubstance P/analysis-
dc.subject.MESHSurveys and Questionnaires-
dc.subject.MESHYoung Adult-
dc.titleAssociation of stress with symptoms of atopic dermatitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorSang Ho Oh-
dc.contributor.googleauthorByung Gi Bae-
dc.contributor.googleauthorChang Ook Park-
dc.contributor.googleauthorJi Yeon Noh-
dc.contributor.googleauthorIl Ho Park-
dc.contributor.googleauthorWen Hao Wu-
dc.contributor.googleauthorKwang Hoon Lee-
dc.identifier.doi10.2340/00015555-0933-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01716-
dc.contributor.localIdA02370-
dc.contributor.localIdA02674-
dc.relation.journalcodeJ00012-
dc.identifier.eissn1651-2057-
dc.identifier.pmid21057740-
dc.subject.keywordstress-
dc.subject.keywordquestionnaire-
dc.subject.keywordatopic dermatitis-
dc.subject.keywordneuropeptide Y-
dc.subject.keywordnerve growth factor-
dc.contributor.alternativeNamePark, Chang Ook-
dc.contributor.alternativeNameOh, Sang Ho-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.affiliatedAuthorPark, Chang Ook-
dc.contributor.affiliatedAuthorOh, Sang Ho-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.citation.volume90-
dc.citation.number6-
dc.citation.startPage582-
dc.citation.endPage588-
dc.identifier.bibliographicCitationACTA DERMATO-VENEREOLOGICA, Vol.90(6) : 582-588, 2010-
dc.identifier.rimsid51594-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.