Cited 11 times in
Absence of activating mutations of CXCR4 in pituitary tumours.
DC Field | Value | Language |
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dc.contributor.author | 노태웅 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2015-04-23T17:17:49Z | - |
dc.date.available | 2015-04-23T17:17:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102193 | - |
dc.description.abstract | OBJECTIVE: Mutations of the gsp oncogene are responsible for 30-40% of GH-producing pituitary adenomas and 10% of nonfunctioning pituitary adenomas (NFPAs). However, the pathogenetic mechanism of the remaining pituitary tumours still remains to be identified. Recently, the interaction between the chemokine stromal cell-derived factor 1 and its receptor CXCR4 was found to play an important role in GH production and cell proliferation in various pituitary adenoma cell lines. As CXCR4 is a Gi-coupled chemokine receptor, its constitutive activating mutations may be involved in pituitary tumour formation by cyclic adenosine monophosphate (cAMP)-independent, ERK-related pathways. PATIENTS AND METHODS: We investigated whether somatic activating-mutations of CXCR4 might be a possible tumourigenic mechanism for gsp-negative GH-secreting pituitary adenomas and NFPAs. Direct sequencing of polymerase chain reaction-amplified products for coding exons of CXCR4 were performed using genomic deoxyribonucleic acid samples from 37 GH-producing pituitary tumour tissues that were negative for the gsp mutation and 14 CXCR4 expressing NFPAs. RESULTS: Immunohistochemical analyses and double immunofluorescent staining of sectioned paraffin-embedded pituitary tissues revealed that CXCR4 is highly expressed in GH-producing pituitary adenomas and NFPAs. Direct sequencing showed that two synonymous mutations in exon 2 (87 C > T and 414 C > T) were detected in 4 out of 51 pituitary tumours. CONCLUSION: Our results indicate that an activating mutation of the CXCR4 may not be a common pathogenetic mechanism in GH-producing pituitary tumours and NFPAs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 209~213 | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/genetics | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Pituitary Neoplasms/genetics* | - |
dc.subject.MESH | Pituitary Neoplasms/metabolism* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Receptors, CXCR4/genetics* | - |
dc.subject.MESH | Receptors, CXCR4/metabolism* | - |
dc.title | Absence of activating mutations of CXCR4 in pituitary tumours. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | Tae Woong Noh | - |
dc.contributor.googleauthor | Mi Kyung Lee | - |
dc.contributor.googleauthor | J. Larry Jameson | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1111/j.1365-2265.2009.03629.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A01298 | - |
dc.relation.journalcode | J00571 | - |
dc.identifier.eissn | 1365-2265 | - |
dc.identifier.pmid | 19473177 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2009.03629.x/abstract | - |
dc.contributor.alternativeName | Noh, Tae Woong | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Noh, Tae Woong | - |
dc.citation.volume | 72 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 209 | - |
dc.citation.endPage | 213 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, Vol.72(2) : 209-213, 2010 | - |
dc.identifier.rimsid | 50011 | - |
dc.type.rims | ART | - |
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