Cited 9 times in
A case of fugitive acromegaly, initially presented as invasive prolactinoma
DC Field | Value | Language |
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dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김선호 | - |
dc.contributor.author | 김태승 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 임정수 | - |
dc.date.accessioned | 2015-04-23T17:17:47Z | - |
dc.date.available | 2015-04-23T17:17:47Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102192 | - |
dc.description.abstract | Fugitive acromegaly is most commonly caused by pituitary acidophil stem cell adenomas, and is characterized by a relatively short clinical history, a large and locally invasive tumor, and relatively low hormonal activity. Here, we report an unusual case of fugitive acromegaly that initially presented as invasive prolactinoma. A 48-year-old man with a huge pituitary mass extending to the suprasellar area was referred to our hospital in December 2007. He had undergone transsphenoidal surgery in November 1999 because of a large invasive prolactinoma. The tumor had grown progressively, despite therapy with dopamine agonists. Subtle features of acromegaly were noted and serum IGF-1 levels were high (733 ng/ml). An oral glucose tolerance test revealed that basal and nadir levels of growth hormone (GH) were 1.56 and 1 ng/ml, respectively. As a therapeutic trial, long-acting octreotide (20 mg IM, monthly) was added, and the tumor size markedly reduced within 6 months on magnetic resonance imaging examination. Immunohistochemical staining of the tumor tissue obtained at the surgery in 1999 showed positive staining for GH and prolactin (PRL). Double immunofluorescence staining showed a mixed positivity for GH and PRL in the majority of tumor cells; however, the two hormones colocalized in a minority of tumor cells, indicating that the tumor was composed of three different cell types (GH, PRL, and GH/PRL). The diagnosis of fugitive acromegaly was initially overlooked in this patient because of normal serum GH levels and a lack of acromegalic features, although histological evidence for GH production was present. IGF-1 determinations would be helpful for the diagnosis of fugitive acromegaly | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~5 | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acromegaly/etiology* | - |
dc.subject.MESH | Acromegaly/pathology* | - |
dc.subject.MESH | Human Growth Hormone/blood | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin-Like Growth Factor I/metabolism | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Pituitary Neoplasms/complications* | - |
dc.subject.MESH | Pituitary Neoplasms/pathology* | - |
dc.subject.MESH | Prolactin/blood | - |
dc.subject.MESH | Prolactinoma/complications* | - |
dc.subject.MESH | Prolactinoma/pathology* | - |
dc.title | A case of fugitive acromegaly, initially presented as invasive prolactinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jung Soo Lim | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Mi-Kyung Lee | - |
dc.contributor.googleauthor | Tai Seung Kim | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1007/s12020-010-9341-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00560 | - |
dc.contributor.localId | A01071 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03401 | - |
dc.relation.journalcode | J00768 | - |
dc.identifier.eissn | 1559-0100 | - |
dc.identifier.pmid | 20960094 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12020-010-9341-5 | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.alternativeName | Kim, Tai Seung | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lim, Jung Soo | - |
dc.contributor.affiliatedAuthor | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tai Seung | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lim, Jung Soo | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, Vol.38(1) : 1-5, 2010 | - |
dc.identifier.rimsid | 50010 | - |
dc.type.rims | ART | - |
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