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RAGE ligands induce apoptotic cell death of pancreatic β-cells via oxidative stress
DC Field | Value | Language |
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dc.contributor.author | 이병완 | - |
dc.date.accessioned | 2015-04-23T17:15:50Z | - |
dc.date.available | 2015-04-23T17:15:50Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102131 | - |
dc.description.abstract | Activation of the receptor for advanced glycation endproducts (RAGE) by its ligands leads to cellular damage contributing to diabetic complications. It is not clearly known whether RAGE ligands influence pancreatic β-cells. In this study, we investigated the expression of RAGE in islet cells and the effect of RAGE ligands, S100b and HMG-1, on islet cells. RAGE was expressed in INS-1 cells and isolated rat and human islets at mRNA and protein levels. RAGE and its ligand, S100b, were detected on islet cells in 28-week-old diabetic OLETF rats. Both S100b and HMG-1 induced apoptotic cell death of INS-1 and islet cells. This INS-1 cell apoptosis was accompanied by increased intracellular oxidative stress and inhibited by antioxidants or a NADPH oxidase inhibitor. Our results showing S100b/RAGE expression on islets of diabetic rat model and RAGE ligands-induced islet cell apoptosis via NADPH oxidase-mediated ROS generation suggest that RAGE ligands-RAGE interaction may contribute not only to the development of diabetic complications but also to the progressive β-cell loss in type 2 diabetes by inducing oxidative stress. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 813~818 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | HMGB1 Protein/pharmacology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Insulin-Secreting Cells/metabolism* | - |
dc.subject.MESH | Islets of Langerhans/cytology | - |
dc.subject.MESH | Islets of Langerhans/metabolism | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nerve Growth Factors/biosynthesis | - |
dc.subject.MESH | Nerve Growth Factors/metabolism | - |
dc.subject.MESH | Nerve Growth Factors/pharmacology* | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred OLETF | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor for Advanced Glycation End Products | - |
dc.subject.MESH | Receptors, Immunologic/biosynthesis | - |
dc.subject.MESH | Receptors, Immunologic/genetics | - |
dc.subject.MESH | Receptors, Immunologic/metabolism* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | S100 Calcium Binding Protein beta Subunit | - |
dc.subject.MESH | S100 Proteins/biosynthesis | - |
dc.subject.MESH | S100 Proteins/metabolism | - |
dc.subject.MESH | S100 Proteins/pharmacology* | - |
dc.subject.MESH | Swine | - |
dc.title | RAGE ligands induce apoptotic cell death of pancreatic β-cells via oxidative stress | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Hee Young Chae | - |
dc.contributor.googleauthor | Soo Jin Kwon | - |
dc.contributor.googleauthor | So Youn Park | - |
dc.contributor.googleauthor | Jahei Ihm | - |
dc.contributor.googleauthor | Sung-Hee Ihm | - |
dc.identifier.doi | 10.3892/ijmm_00000529 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02796 | - |
dc.relation.journalcode | J01132 | - |
dc.identifier.eissn | 1791-244X | - |
dc.identifier.pmid | 21042774 | - |
dc.identifier.url | http://www.spandidos-publications.com/ijmm/26/6/813?text=abstract | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.citation.volume | 26 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 813 | - |
dc.citation.endPage | 818 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.26(6) : 813-818, 2010 | - |
dc.identifier.rimsid | 49964 | - |
dc.type.rims | ART | - |
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