Cited 6 times in
Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study.
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2015-04-23T17:15:15Z | - |
dc.date.available | 2015-04-23T17:15:15Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102113 | - |
dc.description.abstract | According to a previous review, multiple mucosa-associated lymphoid tissue (MALT)-organs involving marginal zone B cell lymphomas (MZLs) are present in 10-30% of patients. However, the clinical features and specific relationships among involved organs are yet to be clearly identified. In this study, we conducted retrospective analyses of multiple MALT organs involving MZLs (MM-MZLs) to identify their clinical features, treatment, prognosis, and specific relationships among involved organs. For analysis, between June 1987 and June 2009, a total of 55 patients from 17 different institutions in Korea, all of whom were histologically diagnosed with MM-MZL, were included in this study. MM-MZL was defined as MZL involving more than 2 different MALT organs. Multiple involvements within one MALT organ (e.g. both side ocular lesions, multiple lung nodules, and multiple stomach lesions, etc.) were excluded from this study. The male/female ratio of the 55 patients was 41/14. The median age of our subjects was 59 years (range 30-82 years). MM-MZL without lymph node (LN) was detected only in 9 patients (36.2%). Bone marrow (BM) involvement was observed in 17 patients (30.9%). The most common site of involvement was the gastrointestinal (GI) tract (25 patients, 45.5%) followed by the lung (40%), Waldeyer's ring (WR) (27.3%), and ocular area (25.5%). Ocular MZLs were commonly accompanied with WR- or lung-MZLs. GI-MZLs were WR or GI-MZLs. Lung-MZLs were frequently observed with ocular and GI-MZLs. WR-MZLs were ocular or GI-MZLs. A total of 53 patients were treated, and 2 on watchful wait. As much as 48 patients received chemotherapy-based treatment. Among them, CR or PR was achieved in 38 patients (79.2%, 95% CI 67-91%). Median time to progression (TTP) was 2.3 years (95% CI 1.4-3.2 years). Cause-specific overall survival (OS) did not reach the median value. The 5-year OS rate was 84.9%. MM-MZLs tend to be an indolent disease, characterized by prolonged survival with frequent relapses. The majority of cases could be controlled effectively via chemotherapy-based treatment, and prolonged survival was achieved in those patients. The GI, lung, WR, and ocular area were commonly presented with other MALT site MZLs, and an organ-specific relationship appears to be relevant to MM-MZLs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 510~517 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Lymphoma, B-Cell, Marginal Zone/diagnosis | - |
dc.subject.MESH | Lymphoma, B-Cell, Marginal Zone/pathology* | - |
dc.subject.MESH | Lymphoma, B-Cell, Marginal Zone/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sung Yong Oh | - |
dc.contributor.googleauthor | Won Seog Kim | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Seok Jin Kim | - |
dc.contributor.googleauthor | Suee Lee | - |
dc.contributor.googleauthor | Dae Ho Lee | - |
dc.contributor.googleauthor | Jong-Ho Won | - |
dc.contributor.googleauthor | In Gyu Hwang | - |
dc.contributor.googleauthor | Min Kyoung Kim | - |
dc.contributor.googleauthor | Soon Il Lee | - |
dc.contributor.googleauthor | Yee Soo Chae | - |
dc.contributor.googleauthor | Deok-Hwan Yang | - |
dc.contributor.googleauthor | Hye Jin Kang | - |
dc.contributor.googleauthor | Chul Won Choi | - |
dc.contributor.googleauthor | Jinny Park | - |
dc.contributor.googleauthor | Hyo Jung Kim | - |
dc.contributor.googleauthor | Jung Hye Kwon | - |
dc.contributor.googleauthor | Ho Sup Lee | - |
dc.contributor.googleauthor | Gyeong-Won Lee | - |
dc.contributor.googleauthor | Hyeon Seok Eom | - |
dc.contributor.googleauthor | Jae-Yong Kwak | - |
dc.contributor.googleauthor | Won Sik Lee | - |
dc.contributor.googleauthor | Cheolwon Suh | - |
dc.contributor.googleauthor | Hyo-Jin Kim | - |
dc.identifier.doi | 10.1007/s12185-010-0680-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J01120 | - |
dc.identifier.eissn | 1865-3774 | - |
dc.identifier.pmid | 20838958 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12185-010-0680-z | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.citation.volume | 92 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 510 | - |
dc.citation.endPage | 517 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.92(3) : 510-517, 2010 | - |
dc.identifier.rimsid | 49554 | - |
dc.type.rims | ART | - |
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