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Effect of primate bone marrow stromal cells on survival and neurite outgrowth

Authors
 Keung Nyun Kim  ;  James D. Guest  ;  Jin Soo Oh  ;  William A. Pennant  ;  Do Heum Yoon  ;  Yoon Ha 
Citation
 NEUROREPORT, Vol.21(13) : 877-881, 2010 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2010
MeSH
Animals ; Bone Marrow Cells/physiology* ; Cell Count ; Cell Survival/physiology ; Coculture Techniques ; Culture Media, Conditioned ; Cytokines/biosynthesis ; Ganglia, Spinal/cytology ; Immunohistochemistry ; Macaca fascicularis ; Male ; Neurites/physiology* ; Stromal Cells/transplantation*
Abstract
We tested whether bone marrow stromal cells (BMSCs) could enhance the survival and neurite growth of dorsal root ganglia (DRG) through substrate effects or secreted factors. Our results showed that in DRG with BMSCs and BMSC-conditioned media cultures compared with DRG-fibroblast cultures, there was a significant increase in the number and length of, area covered by, and number of cells with definite neurites. In cytokine assays with conditioned media, vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and IL-6 secreted by BMSCs may contribute to observed neurotrophic effects. These findings indicate that BMSCs of adult Macaca fascicularis increased neuronal survival and promoted neurite outgrowth of DRG by means of secretory factors.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201009150-00006&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e32833da3a6
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Oh, Jin Soo(오진수)
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Ha, Yoon(하윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102080
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