0 528

Cited 10 times in

The effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation

DC Field Value Language
dc.contributor.author김경래-
dc.contributor.author남지선-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author유정선-
dc.contributor.author이은직-
dc.contributor.author이현철-
dc.contributor.author임승길-
dc.contributor.author조민호-
dc.contributor.author차봉수-
dc.date.accessioned2015-04-23T17:14:03Z-
dc.date.available2015-04-23T17:14:03Z-
dc.date.issued2010-
dc.identifier.issn0168-8227-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102075-
dc.description.abstractAIMS: We investigated the effect of mosapride, 5HT-4 (5-hydroxytryptamine) agonist, on blood glucose level and insulin sensitivity in subjects with impaired glucose tolerance (IGT) and conducted an in vitro study to evaluate the action mechanism. METHODS: Thirty IGT patients were randomly assigned to receive either mosapride or placebo for 2 weeks. Biochemical profiles and insulin sensitivity index from euglycemic hyperinsulinemic clamp test were assessed before and after treatment. In cultured myotubes from human skeletal muscle cells, insulin- and mosapride-induced GLUT4 translocation and tyrosine phosphorylation of IRS-1 were determined. RESULTS: After 2 weeks of treatment with mosapride, glucose disposal rates were significantly increased up to those of control (mosapride 5.47+/-1.72 vs 7.06+/-2.13, P=0.004, placebo 5.42+/-1.85 vs 5.23+/-1.53mgkg(-1)min(-1)). Fasting plasma glucose (FPG) and insulin levels were decreased. Mosapride increased the contents of GLUT4 in plasma membrane representing the increased recruitment of glucose transporters from intracellular pool. While insulin treatment on human skeletal muscle cell resulted in an increased tyrosine phosphorylation of IRS-1, mosapride did not have any effect. CONCLUSIONS: Mosapride is effective in decreasing FPG without stimulating insulin secretion in IGT subjects, possibly by inducing GLUT4 translocation in skeletal muscles.-
dc.description.statementOfResponsibilityopen-
dc.format.extent329~334-
dc.relation.isPartOfDIABETES RESEARCH AND CLINICAL PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBenzamides/pharmacology*-
dc.subject.MESHBlood Glucose/drug effects*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCells, Cultured-
dc.subject.MESHFemale-
dc.subject.MESHGlucose Clamp Technique-
dc.subject.MESHGlucose Transporter Type 4/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoassay-
dc.subject.MESHInsulin Receptor Substrate Proteins/metabolism-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHLipids/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMorpholines/pharmacology*-
dc.subject.MESHMuscle, Skeletal/cytology-
dc.subject.MESHMuscle, Skeletal/drug effects-
dc.subject.MESHPhosphorylation/drug effects-
dc.subject.MESHProtein Transport/drug effects-
dc.subject.MESHSingle-Blind Method-
dc.titleThe effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJ.S. Nam-
dc.contributor.googleauthorJ.Y. Nam-
dc.contributor.googleauthorJ.S. Yoo-
dc.contributor.googleauthorM. Cho-
dc.contributor.googleauthorJ.S. Park-
dc.contributor.googleauthorC.W. Ahn-
dc.contributor.googleauthorB.S. Cha-
dc.contributor.googleauthorE.J. Lee-
dc.contributor.googleauthorS.K. Lim-
dc.contributor.googleauthorK.R. Kim-
dc.contributor.googleauthorH.C. Lee-
dc.identifier.doi10.1016/j.diabres.2009.12.021-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00294-
dc.contributor.localIdA01268-
dc.contributor.localIdA02270-
dc.contributor.localIdA02499-
dc.contributor.localIdA03050-
dc.contributor.localIdA03301-
dc.contributor.localIdA03375-
dc.contributor.localIdA03819-
dc.contributor.localIdA03996-
dc.contributor.localIdA01660-
dc.relation.journalcodeJ00723-
dc.identifier.eissn1872-8227-
dc.identifier.pmid20060191-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0168822709005464-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameNam, Ji Sun-
dc.contributor.alternativeNamePark, Jong Suk-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameYoo, Jeong Seon-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCho, Min Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Kyung Rae-
dc.contributor.affiliatedAuthorNam, Ji Sun-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorYoo, Jeong Seon-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorCho, Min Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorPark, Jong Suk-
dc.citation.volume87-
dc.citation.number3-
dc.citation.startPage329-
dc.citation.endPage334-
dc.identifier.bibliographicCitationDIABETES RESEARCH AND CLINICAL PRACTICE, Vol.87(3) : 329-334, 2010-
dc.identifier.rimsid52707-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.