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비당뇨병성 말기신부전 환자에서 심혈관질환 발생의 예측 인자로서 아디포넥틴의 유용성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박형천 | - |
dc.contributor.author | 이용규 | - |
dc.contributor.author | 하성규 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김좌경 | - |
dc.contributor.author | 문성진 | - |
dc.date.accessioned | 2015-04-23T17:13:45Z | - |
dc.date.available | 2015-04-23T17:13:45Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1975-9460 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102066 | - |
dc.description.abstract | Purpose: Adiponectin (ADPN) has been known to protect against cardiovascular disease (CVD) in metabolic syndrome with normal renal function for its anti-inflammatory and anti-atherogenic property. However, it is still unclear whether ADPN is associated with cardiovascular outcomes in end-stage renal disease (ESRD) patients. Methods: This study included 80 non-diabetic ESRD patients [mean age, 52.8±13.7 years; dialysis duration, 67.1±52.0 months; hemodialysis (HD), 35 pts; peritoneal dialysis (PD), 45 pts] who survived for more than 3 months after the start of dialysis, and serum ADPN levels were measured at the beginning of the study. We conducted a longitudinal follow-up to evaluate the association of serum ADPN level with cardiovascular outcomes for 29.3±6.7 months. Results: ADPN was inversely correlated with fasting serum insulin (r=-0.309, p=0.006) and HOMA-IR (r=-0.321, p=0.004) in ESRD patients. In a multiple linear regression analysis adjusted for age, gender, waist to hip ratio (WHR), and HDL-cholesterol, HOMA-IR (β=-0.880, p=0.041) was an independent factor associated with serum ADPN level. Kaplan-Meier analysis revealed that patients with higher ADPN levels (≥15.8 μg/mL) had a significantly higher survival rate compared with lowers (<15.8 μg/ mL) (p=0.032). Cox proportional hazard model adjusted for age, WHR, creatinine, CRP, and previous CVD history revealed that serum ADPN level (HR, 0.899; 95% CI, 0.818-0.987; p=0.026) was an independent determinant of cardiovascular outcomes. Conclusion: These findings suggest that lower ADPN levels independently predict cardiovascular events in non-diabetic ESRD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 465~473 | - |
dc.relation.isPartOf | Korean Journal of Nephrology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 비당뇨병성 말기신부전 환자에서 심혈관질환 발생의 예측 인자로서 아디포넥틴의 유용성 | - |
dc.title.alternative | Serum Adiponectin as a Predictor for Cardiovascular Outcomes in Non-Diabetic End-Stage Renal Disease Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 안혜림 | - |
dc.contributor.googleauthor | 문성진 | - |
dc.contributor.googleauthor | 박형천 | - |
dc.contributor.googleauthor | 이용규 | - |
dc.contributor.googleauthor | 김좌경 | - |
dc.contributor.googleauthor | 김범석 | - |
dc.contributor.googleauthor | 김형종 | - |
dc.contributor.googleauthor | 한대석 | - |
dc.contributor.googleauthor | 하성규 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A02975 | - |
dc.contributor.localId | A04252 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00931 | - |
dc.contributor.localId | A01364 | - |
dc.relation.journalcode | J02065 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | End-stage renal disease | - |
dc.subject.keyword | Cardiovascular disease | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Lee, Yong Kyu | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Jwa Kyung | - |
dc.contributor.alternativeName | Moon, Sung Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Lee, Yong Kyu | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jwa Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Sung Jin | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 473 | - |
dc.identifier.bibliographicCitation | Korean Journal of Nephrology, Vol.29(4) : 465-473, 2010 | - |
dc.identifier.rimsid | 52700 | - |
dc.type.rims | ART | - |
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