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바이오리액터 개발과 기계적 자극에 의한 중간엽 줄기세포의 영향에 관한 연구

Other Titles
 Development of Bioreactor for Regenerative Medicine and Effect of Mechanical Stimuli on Mesenchymal Stem Cells in Polyurethane Scaffolds 
Authors
 주민진  ;  전흥재  ;  정형진  ;  이창근  ;  허동녕  ;  권일근  ;  문성환 
Citation
 TRANSACTIONS OF THE KOREAN SOCIETY OF MECHANICAL ENGINEERS A, Vol.34(6) : 675-681, 2010 
Journal Title
 TRANSACTIONS OF THE KOREAN SOCIETY OF MECHANICAL ENGINEERS A 
ISSN
 1226-4873 
Issue Date
2010
Keywords
Bioreactor ; Mechanical Stimulation ; Mesenchymal Stem Cell ; Polyurethane Scaffold
Abstract
It is well known that mesenchymal stem cell(MSCs) can be differentiated into fibroblasts, chondrocytes, and osteoblasts and that they develop into fibrous tissue, cartilage, or bone, as a result of mechanical stimulation. In this study, we developed a bioreactor system, which is composed of a reactor vessel that provides the required cell culture environment, an environment controlling chamber to control the media, a gas mixer, and a reactor motion control subsystem to apply mechanical stimuli to the cells. For the MSC culture, We used a poly-urethane (PU) scaffold, with a collagen coating to ensure improved cohesion ratio. Then, we transferred the cultivated MSCs in the PU scaffold, cultured the cells in the bioreactor system, and confirmed the proliferation, differentiation, and ossification processes, resulting from mechanical stimuli.
Files in This Item:
T201003228.pdf Download
DOI
10.3795/KSME-A.2010.34.6.675
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seong Hwan(문성환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102053
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