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Extensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases--a multicentre study

DC FieldValueLanguage
dc.contributor.author한상훈-
dc.contributor.author김준명-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author진범식-
dc.date.accessioned2015-04-23T17:12:05Z-
dc.date.available2015-04-23T17:12:05Z-
dc.date.issued2010-
dc.identifier.issn0924-8579-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102014-
dc.description.abstractIn this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case-control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR)=9.6, 95% confidence interval (CI) 1.3-171.3; P=0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR=1.2, 95% CI 1.1-1.5; P=0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals-
dc.description.statementOfResponsibilityopen-
dc.format.extent430~435-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcinetobacter Infections/epidemiology*-
dc.subject.MESHAcinetobacter Infections/microbiology*-
dc.subject.MESHAcinetobacter Infections/pathology-
dc.subject.MESHAcinetobacter baumannii/classification-
dc.subject.MESHAcinetobacter baumannii/drug effects*-
dc.subject.MESHAcinetobacter baumannii/enzymology*-
dc.subject.MESHAcinetobacter baumannii/genetics-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHBacterial Proteins/biosynthesis*-
dc.subject.MESHBacterial Typing Techniques-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCross Infection/epidemiology-
dc.subject.MESHCross Infection/microbiology-
dc.subject.MESHCross Infection/pathology-
dc.subject.MESHDNA Fingerprinting-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHospitals-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHbeta-Lactam Resistance*-
dc.subject.MESHbeta-Lactamases/biosynthesis*-
dc.titleExtensively drug-resistant Acinetobacter baumannii: risk factors for acquisition and prevalent OXA-type carbapenemases--a multicentre study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorYoon Soo Park-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorKkot Sil Lee-
dc.contributor.googleauthorSeung Sik Hwang-
dc.contributor.googleauthorYong Kyun Cho-
dc.contributor.googleauthorHyo Youl Kim-
dc.contributor.googleauthorYoung Uh-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1016/j.ijantimicag.2010.06.049-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04286-
dc.contributor.localIdA00953-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA03981-
dc.relation.journalcodeJ01088-
dc.identifier.eissn1872-7913-
dc.identifier.pmid20864318-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0924857910003365-
dc.subject.keywordRisk factor-
dc.subject.keywordExtensive drug resistance-
dc.subject.keywordAcinetobacter baumannii-
dc.subject.keywordOXA carbapenemase-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage430-
dc.citation.endPage435-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol.36(5) : 430-435, 2010-
dc.identifier.rimsid52657-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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