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Innate immune responses of the airway epithelium.

Authors
 Ji-Hwan Ryu  ;  Chang-Hoon Kim  ;  Joo-Heon Yoon 
Citation
 MOLECULES AND CELLS, Vol.30(3) : 173-183, 2010 
Journal Title
 MOLECULES AND CELLS 
ISSN
 1016-8478 
Issue Date
2010
MeSH
Adaptive Immunity ; Animals ; Antimicrobial Cationic Peptides/immunology ; Cell Communication ; Cytokines/immunology* ; Humans ; Immunity, Innate* ; Mucins/immunology ; Reactive Oxygen Species ; Respiratory Mucosa/immunology* ; Respiratory Tract Infections/immunology*
Keywords
airway epithelium ; antimicrobial peptides ; innate immune responses ; Mucin ; pattern recognition receptor ; reactive oxygen species ; respiratory viruses
Abstract
Barrier epithelia, especially airway epithelial cells, are persistently exposed to micro-organisms and environmental factors. To protect the host from these microbial challenges, many immune strategies have evolved. The airway epithelium participates in the critical innate immune response through the secretion of immune effectors such as mucin, antimicrobial peptides (AMP), and reactive oxygen species (ROS) to entrap or kill invading microbes. In addition, airway epithelial cells can act as mediators connecting innate and adaptive immunity by producing various cytokines and chemokines. Here, we present an overview of the role of mucosal immunity in airway epithelium, emphasizing the framework of bacterial and viral infections along with regulatory mechanisms of immune effectors in human cells and selected animal models. We also describe pathophysiological roles for immune effectors in human airway disease.
Full Text
http://link.springer.com/article/10.1007%2Fs10059-010-0146-4
DOI
10.1007/s10059-010-0146-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Ryu, Ji Hwan(유지환)
Yoon, Joo Heon(윤주헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102004
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