Cited 17 times in
Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ω6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T17:10:38Z | - |
dc.date.available | 2015-04-23T17:10:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-2275 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101967 | - |
dc.description.abstract | We determined the contribution of the combination of FEN1 10154G>T with the most significant association in the analysis of plasma arachidonic acid (AA, 20:4ω6) and the APOA5-1131T>C on phospholipid ω6PUFA and coronary artery disease (CAD). Patients with CAD (n = 807, 27-81 years of age) and healthy controls (n = 1123) were genotyped for FEN1 10154G>T and APOA5-1131T>C. We found a significant interaction between these two genes for CAD risk (P = 0.007) adjusted for confounding factors. APOA5-1131C allele carriers had a higher CAD risk [odds ratio (OR):1.484, 95% confidence interval (CI):1.31-1.96; P = 0.005] compared with APOA5-1131TT individuals in the FEN1 10154GG genotype group but not in the FEN1 10154T allele group (OR:1.096, 95%CI:0.84-1.43; P = 0.504). Significant interactions between these two genes were also observed for the AA proportion (P = 0.04) and the ratio of AA/linoleic acid (LA, 18:2ω6) (P = 0.004) in serum phospholipids of controls. The APOA5-1131C allele was associated with lower AA (P = 0.027) and AA/LA (P = 0.014) only in controls carrying the FEN1 10154T allele. In conclusion, the interaction between these genes suggests that the FEN1 10154T variant allele decreases AA and AA/LA in the serum phospholipids of carriers of the APOA5-1131C allele, but contributes no significant increase in CAD risk for this population subset despite their increased triglylcerides and decreased apoA5. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3281~3288 | - |
dc.relation.isPartOf | JOURNAL OF LIPID RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Apolipoprotein A-V | - |
dc.subject.MESH | Apolipoproteins A/genetics* | - |
dc.subject.MESH | Arachidonic Acids/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Coronary Artery Disease/blood* | - |
dc.subject.MESH | Coronary Artery Disease/genetics* | - |
dc.subject.MESH | Coronary Artery Disease/metabolism | - |
dc.subject.MESH | Fatty Acids, Omega-6/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flap Endonucleases/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipid Peroxides/blood | - |
dc.subject.MESH | Lipoproteins, LDL/blood | - |
dc.subject.MESH | Lipoproteins, LDL/chemistry | - |
dc.subject.MESH | Lipoproteins, LDL/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Phospholipids/blood* | - |
dc.subject.MESH | Phospholipids/chemistry | - |
dc.subject.MESH | Phospholipids/metabolism | - |
dc.subject.MESH | Polymorphism, Single Nucleotide* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood | - |
dc.title | Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ω6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ju Yeon Park | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1194/jlr.M010330 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01563 | - |
dc.identifier.eissn | 1539-7262 | - |
dc.identifier.pmid | 20802161 | - |
dc.subject.keyword | arachidonic acid | - |
dc.subject.keyword | linoleic acid | - |
dc.subject.keyword | CAD risk | - |
dc.subject.keyword | apolipoprotein A5 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 51 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3281 | - |
dc.citation.endPage | 3288 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LIPID RESEARCH, Vol.51(11) : 3281-3288, 2010 | - |
dc.identifier.rimsid | 50978 | - |
dc.type.rims | ART | - |
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