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Ischemia-modified albumin: is it a reliable diagnostic and prognostic marker for myocardial ischemia in real clinical practice?

 Kim J.-S.  ;  Hwang H.J.  ;  Ko Y.-G.  ;  Kim J.-S.  ;  Choi D.  ;  Ha J.-W.  ;  Hong M.-K.  ;  Jang Y 
 CARDIOLOGY, Vol.116(2) : 123-129, 2010 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism* ; Chest Pain/blood ; Chest Pain/diagnosis ; Chest Pain/mortality ; Coronary Vasospasm/blood ; Coronary Vasospasm/diagnosis ; Coronary Vasospasm/mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myocardial Ischemia*/blood ; Myocardial Ischemia*/diagnosis ; Myocardial Ischemia*/mortality ; Predictive Value of Tests ; Serum Albumin/metabolism*
Biomarker ; Coronary artery disease ; Ischemia-modified albumin ; Myocardial ischemia
OBJECTIVES: We investigated whether ischemia-modified albumin (IMA), a novel biomarker of acute myocardial ischemia, is reliable for diagnosing ischemic chest pain and predicting future cardiac events in clinical practice. METHODS: We enrolled 390 patients (age 61.7 +/- 39.9 years) who arrived at the emergency department within 6 h of pain onset. We compared serum IMA levels of patients with ischemic chest pain (ICP) to those with nonischemic chest pain (NICP). RESULTS: NICP was diagnosed in 162 patients and ICP in 205 patients. Median serum IMA levels did not differ between the NICP (99.0 U/ml; 95% confidence interval, 98.2-101.2 U/ml) and the ICP group (99.0 U/ml; 95% confidence interval, 99.4-102.6 U/ml; p = 0.320). During a 2-year follow-up, adverse cardiac events including cardiac death, myocardial infarction and recurrent angina occurred in 25 of 205 patients (12.2%) in the ICP group, but IMA was not predictive of cardiac events. CONCLUSIONS: IMA was neither able to discriminate acute chest pain due to myocardial ischemia from that of other origin nor to predict cardiac events. Therefore, use of serum IMA levels for triage of patients with acute chest pain does not seem effective in clinical practice
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Jin Sun(김진선)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
Hwang, Hye Jin(황혜진)
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