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Metastatic breast cancer shows different immunohistochemical phenotype according to metastatic site
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2015-04-23T17:09:17Z | - |
dc.date.available | 2015-04-23T17:09:17Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0300-8916 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101924 | - |
dc.description.abstract | AIMS AND BACKGROUND: The study was performed to assess the status of immunohistochemical markers in primary and metastatic breast cancer and to determine the organ-specific characteristics of metastatic breast cancer. METHODS: Samples from 13 cases of paired primary and metastatic breast cancer and 34 cases of metastatic breast cancer were included. RESULTS: In the analysis of 13 cases of paired primary and metastatic breast cancer, estrogen receptor and progesterone receptor loss were noted in 1 (7.7%) case each. Androgen receptor loss and gain was noted in 2 (15.4%) cases, respectively. HER-2 showed 100% concordance with primary and metastatic tumors. C-kit was demonstrated in only 2 (15.4%) cases of metastatic breast cancer. In the analysis of 34 cases of metastatic breast cancer, when classified into triple-negative type (ER-, PR-, and HER-2-), HER-2+ type, and ER+ or PR+/HER-2- type according to immunohistochemical stain results, HER-2 type (66.7%) in brain metastasis and ER+ or PR+/HER-2- type (75.0%) in liver metastasis were predominant. Bone metastasis was composed of triple negative type (44.4%) and ER+ or PR+/HER-2- type (55.6%), and lung metastasis showed all of three subtypes in similar proportions. CONCLUSIONS: Metastatic breast cancer shows different immunohistochemical phenotypes according to metastatic site (P = 0.048). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 424~432 | - |
dc.relation.isPartOf | TUMORI J | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Breast Neoplasms/chemistry* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Receptor, ErbB-2/analysis | - |
dc.subject.MESH | Receptors, Estrogen/analysis | - |
dc.subject.MESH | Receptors, Progesterone/analysis | - |
dc.subject.MESH | Sampling Studies | - |
dc.title | Metastatic breast cancer shows different immunohistochemical phenotype according to metastatic site | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Woohee Jung | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1700/499.5922 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J02764 | - |
dc.identifier.eissn | 2038-2529 | - |
dc.identifier.pmid | 20845803 | - |
dc.identifier.url | http://www.tumorionline.it/articoli.php?archivio=yes&vol_id=499&id=5922 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 96 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 424 | - |
dc.citation.endPage | 432 | - |
dc.identifier.bibliographicCitation | TUMORI J, Vol.96(3) : 424-432, 2010 | - |
dc.identifier.rimsid | 50948 | - |
dc.type.rims | ART | - |
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