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Identification of streptococcal proteins reacting with sera from Behçet's disease and rheumatic disorders
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 방동식 | - |
dc.contributor.author | 안근재 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 이주희 | - |
dc.contributor.author | 조성빈 | - |
dc.date.accessioned | 2015-04-23T17:07:34Z | - |
dc.date.available | 2015-04-23T17:07:34Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101869 | - |
dc.description.abstract | OBJECTIVES: We evaluated the reactivity of sera from Behçet's disease (BD), systemic lupus erythematosus (SLE), dermatomyositis (DM), rheumatoid arthritis (RA), and Takayasu's arteritis (TA) patients against human α-enolase and streptococcal α-enolase, and identified additional streptococcal antigens. METHODS: Enzyme-linked immunosorbent assay (ELISA) and immunoblotting were performed using sera from patients with BD, SLE, DM, RA, and TA and healthy volunteers (control) against human α-enolase and streptococcal α-enolase. Immunoblot analysis and matrix-assisted laser desorption ionisation-time-of-flight mass spectrometry were used to identify and recombine other streptococcal antigens. RESULTS: Specific positive signals against recombinant human α-enolase were detected by IgM ELISA of serum samples from 50% of BD, 14.3% of SLE, 57.1% of DM, 42.9% of RA, and 57.1% of TA patients. Specific positive signals against streptococcal α-enolase were detected from 42.9% of BD, 14.3% of DM, and 14.3% of TA patients. No SLE and RA sera reacted against streptococcal α-enolase antigen. Streptococcal proteins reacting with sera were identified as hypothetical protein (HP) for SLE and DM patients, acid phosphatase (AP) for RA patients, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for TA patients. CONCLUSIONS: We observed that RA patients did not present serum reactivity against either HP or GAPDH though BD, SLE, DM, and TA patients did. Also, AP reacted with sera from BD, SLE, DM, RA, and TA patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | s31~s38 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acid Phosphatase/immunology | - |
dc.subject.MESH | Antibodies, Bacterial/blood* | - |
dc.subject.MESH | Antibodies, Bacterial/immunology | - |
dc.subject.MESH | Antigens, Bacterial/immunology | - |
dc.subject.MESH | Arthritis, Rheumatoid/blood* | - |
dc.subject.MESH | Arthritis, Rheumatoid/immunology | - |
dc.subject.MESH | Bacterial Proteins/immunology* | - |
dc.subject.MESH | Behcet Syndrome/blood* | - |
dc.subject.MESH | Behcet Syndrome/immunology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Dermatomyositis/blood* | - |
dc.subject.MESH | Dermatomyositis/immunology | - |
dc.subject.MESH | Glyceraldehyde-3-Phosphate Dehydrogenases/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/blood* | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/immunology | - |
dc.subject.MESH | Phosphopyruvate Hydratase/immunology | - |
dc.subject.MESH | Streptococcus sanguis* | - |
dc.subject.MESH | Takayasu Arteritis/blood | - |
dc.subject.MESH | Takayasu Arteritis/immunology | - |
dc.title | Identification of streptococcal proteins reacting with sera from Behçet's disease and rheumatic disorders | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | S. Cho | - |
dc.contributor.googleauthor | J. Lee | - |
dc.contributor.googleauthor | K. Ahn | - |
dc.contributor.googleauthor | S. Cho | - |
dc.contributor.googleauthor | Y. Park | - |
dc.contributor.googleauthor | S. Lee | - |
dc.contributor.googleauthor | D. Bang | - |
dc.contributor.googleauthor | K. Lee | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A01784 | - |
dc.contributor.localId | A02222 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A03832 | - |
dc.contributor.localId | A03171 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00555 | - |
dc.identifier.eissn | 1593-098X | - |
dc.identifier.pmid | 20868568 | - |
dc.identifier.url | http://www.clinexprheumatol.org/abstract.asp?a=960 | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | systemic lupus erythematosus | - |
dc.subject.keyword | dermatomyositis | - |
dc.subject.keyword | rheumatoid arthritis | - |
dc.subject.keyword | Takayasu’s arteritis | - |
dc.subject.keyword | enolase | - |
dc.subject.keyword | Streptococcus sanguis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.alternativeName | Ahn, Keun Jae | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Cho, Sung Bin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Keun Jae | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Cho, Sung Bin | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 suppl 60 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.28(4 suppl 60) : 31-38, 2010 | - |
dc.identifier.rimsid | 54661 | - |
dc.type.rims | ART | - |
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