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Synergistic dual automaticity in sinoatrial node cell and tissue models
DC Field | Value | Language |
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dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2015-04-23T17:04:39Z | - |
dc.date.available | 2015-04-23T17:04:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101778 | - |
dc.description.abstract | BACKGROUND: The mechanism of sinoatrial node (SAN) automaticity is traditionally attributed to membrane ion currents. Recent evidence indicates spontaneous sarcoplasmic reticulum (SR) Ca(2+) cycling also plays an important role. METHODS AND RESULTS: A computer simulation on SAN cell and 1D tissue model was performed. In the SAN cells, SR Ca(2+) cycling broadly modulated the sinus rate from 1.74 Hz to 3.87 Hz. Shortening of the junctional SR refilling time and increase of SR Ca(2+) release were responsible for sinus rate acceleration. However, under the fast SR Ca(2+) cycling, decreased L-type Ca(2+) current (I(CaL)) resulted in irregular firing. When Ca(2+) cycling was suppressed, I(f) and I(CaT) both acted to stabilize the pacemaker rhythm, but I(CaT) had less effect than I(f). At the 1D level, the electrical coupling between neighboring cells had little effect on the earliest pacemaker location. The leading pacemaking site always colocalized with the site with the highest SR Ca(2+) cycling rate, but shifted to the site with less inhibited I(CaL). CONCLUSIONS: The rate of SR Ca(2+) cycling can effectively and broadly modulate the sinus rate. I(f), I(CaL) and I(CaT) play integral roles to guarantee SAN cell rhythmic firing. The leading pacemaker site is determined by intracellular Ca(2+) dynamics and membrane currents, indicating the synergistic dual automaticity not only exists in single SAN cells, but also at the tissue level. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2079~2088 | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biological Clocks* | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Calcium Channels, L-Type | - |
dc.subject.MESH | Calcium Channels, T-Type | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Models, Cardiovascular* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Sarcoplasmic Reticulum/metabolism | - |
dc.subject.MESH | Sinoatrial Node/cytology | - |
dc.subject.MESH | Sinoatrial Node/physiology* | - |
dc.title | Synergistic dual automaticity in sinoatrial node cell and tissue models | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hong Zhang | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Tetsuji Shinohara | - |
dc.contributor.googleauthor | Mei Xi | - |
dc.contributor.googleauthor | Peng-Sheng Chen | - |
dc.contributor.googleauthor | Shien-Fong Lin | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J00534 | - |
dc.identifier.eissn | 1347-4820 | - |
dc.identifier.pmid | 20679733 | - |
dc.subject.keyword | Calcium | - |
dc.subject.keyword | Ion channels | - |
dc.subject.keyword | Sarcoplasmic reticulum | - |
dc.subject.keyword | Sinoatrial node | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.citation.volume | 74 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2079 | - |
dc.citation.endPage | 2088 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, Vol.74(10) : 2079-2088, 2010 | - |
dc.identifier.rimsid | 54599 | - |
dc.type.rims | ART | - |
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