Cited 39 times in
Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-04-23T17:04:19Z | - |
dc.date.available | 2015-04-23T17:04:19Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1369-3786 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101768 | - |
dc.description.abstract | Multicenter data on in vitro susceptibility of Candida bloodstream isolates to echinocandin antifungal agents is still lacking in South Korea. We performed a prospective multicenter study to determine the species distribution of Candida bloodstream isolates and their susceptibility to five antifungal agents, including caspofungin and micafungin. A total of 639 isolates were collected from 20 tertiary hospitals between September 2006 and August 2007. Antifungal susceptibilities were determined through the use of the CLSI broth microdilution method M27-A3. The overall species distribution was as follows; Candida albicans (38%), Candida parapsilosis (26%), Candia tropicalis (20%), Candida glabrata (11%), and miscellaneous Candida species (5%). Although C. parapsilosis and miscellaneous Candida species were less susceptible to both echinocandins, all 639 isolates were susceptible to both caspofungin and micafungin (MIC, <or= 2 microg/ml). Nearly all isolates (99.7%) had a MIC <or= 1 microg/ml to amphotericin B. Resistance to fluconazole and voriconazole was found in 0.8% and 0.3%, respectively, among all Candida isolates, with C. glabrata and C. krusei isolates displaying the greatest level of resistance. This is the largest multicenter candidemia study conducted in South Korea and shows that non-C. albicans Candida species, including C. parapsilosis, constitutes over 60% of all Candida species isolates recovered from the bloodstream. In addition, the rates of resistance to all five antifungals, including two echinocandins, are still low among bloodstream isolates in South Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 669~674 | - |
dc.relation.isPartOf | MEDICAL MYCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antifungal Agents/therapeutic use | - |
dc.subject.MESH | Candida/drug effects* | - |
dc.subject.MESH | Candida/isolation & purification | - |
dc.subject.MESH | Candidiasis/drug therapy | - |
dc.subject.MESH | Candidiasis/microbiology* | - |
dc.subject.MESH | Drug Resistance, Fungal | - |
dc.subject.MESH | Fungemia/drug therapy | - |
dc.subject.MESH | Fungemia/microbiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Population Surveillance | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Sook-In Jung | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.contributor.googleauthor | Jae-Hoon Song | - |
dc.contributor.googleauthor | Kyong Ran Peck | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Mi-Na Kim | - |
dc.contributor.googleauthor | Hyun Ha Chang | - |
dc.contributor.googleauthor | Chi Sook Moon | - |
dc.identifier.doi | 10.3109/13693780903410386 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J02204 | - |
dc.identifier.eissn | 1460-2709 | - |
dc.identifier.pmid | 20392145 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/13693780903410386 | - |
dc.subject.keyword | Candida | - |
dc.subject.keyword | antifungal susceptibility | - |
dc.subject.keyword | candidemia | - |
dc.subject.keyword | azoles | - |
dc.subject.keyword | echinocandins | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 669 | - |
dc.citation.endPage | 674 | - |
dc.identifier.bibliographicCitation | MEDICAL MYCOLOGY, Vol.48(4) : 669-674, 2010 | - |
dc.identifier.rimsid | 54589 | - |
dc.type.rims | ART | - |
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