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Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer: is it beneficial?
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 허혁 | - |
dc.contributor.author | 금기창 | - |
dc.date.accessioned | 2015-04-23T17:01:12Z | - |
dc.date.available | 2015-04-23T17:01:12Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0179-1958 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101671 | - |
dc.description.abstract | PURPOSE: The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial. We evaluated the effect of adjuvant chemoradiotherapy (CRT) versus chemotherapy (CT) alone on the local recurrence and survival of patients with stage IIA rectal cancer after TME. METHODS: Between 1996 and 2004, patients with stage IIA rectal cancer who received adjuvant CT (n = 29) or CRT (n = 122) following TME were enrolled. Oncologic outcomes were compared between groups, and risk factors for local recurrence and overall survival rates were analyzed. RESULTS: The median follow-up period was 78 months. No significant differences were observed in the 5-year local recurrence (3.4% versus 9.0%; P = 0.348) or 5-year overall survival rates (86.2% versus 80.3%; P = 0.924) between CT and CRT. However, involvement of the circumferential resection margin and age >60 years were associated with adverse oncologic outcomes. CONCLUSIONS: Additional postoperative radiotherapy did not alter local recurrence or survival after TME in patients with stage IIA rectal cancer. Postoperative radiation may be an overtreatment as an adjuvant therapy in patients with stage IIA rectal cancer if they had no other risk factors. However, randomized controlled trials are warranted to confirm this suggestion. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1103~1110 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/radiotherapy | - |
dc.subject.MESH | Neoplasm Recurrence, Local/surgery | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Postoperative Care | - |
dc.subject.MESH | Postoperative Complications/etiology | - |
dc.subject.MESH | Radiotherapy, Adjuvant/adverse effects | - |
dc.subject.MESH | Rectal Neoplasms/mortality | - |
dc.subject.MESH | Rectal Neoplasms/pathology | - |
dc.subject.MESH | Rectal Neoplasms/radiotherapy* | - |
dc.subject.MESH | Rectal Neoplasms/surgery* | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer: is it beneficial? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jin Soo Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.1007/s00384-010-0970-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A04373 | - |
dc.contributor.localId | A00272 | - |
dc.relation.journalcode | J01100 | - |
dc.identifier.eissn | 1432-1262 | - |
dc.identifier.pmid | 20544208 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00384-010-0970-1 | - |
dc.subject.keyword | Rectal neoplasm | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Adjuvant therapy | - |
dc.subject.keyword | Total mesorectal excision | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Hur, Hyuk | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Hur, Hyuk | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1103 | - |
dc.citation.endPage | 1110 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol.25(9) : 1103-1110, 2010 | - |
dc.identifier.rimsid | 40152 | - |
dc.type.rims | ART | - |
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