Cited 7 times in
Impact of the attainment of current recommended low-density lipoprotein cholesterol goal of less than 70 mg/dl on clinical outcomes in very high-risk patients treated with drug-eluting stents
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김병극 | - |
dc.contributor.author | 박성하 | - |
dc.date.accessioned | 2015-04-23T16:59:20Z | - |
dc.date.available | 2015-04-23T16:59:20Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0954-6928 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101613 | - |
dc.description.abstract | OBJECTIVE: We sought to evaluate whether the attainment of low-density lipoprotein cholesterol (LDL-C) goal of less than 70 mg/dl would affect clinical outcomes in Korean patients treated with drug-eluting stents (DES). BACKGROUND: The current cholesterol guideline has strongly recommended reducing LDL-C to less than 70 mg/dl as the goal of therapy for very high-risk patients. METHODS: From 2003 to 2006, a total of 1347 very high-risk patients were treated with DES. Among them, we identified 578 eligible patients with follow-up LDL-C within 6-8 months after DES and divided these patients into two groups based on the level of follow-up LDL-C: group A, follow-up LDL less than 70 mg/dl (n=234) and group B, LDL of at least 70 mg/dl (n=344). Then we analyzed the incidence of major adverse cardiac and cerebrovascular events [MACCE: death, myocardial infarction, target-vessel revascularization (TVR), non-TVR, cerebrovascular accidents] of both the groups. RESULTS: During the follow-up (mean duration=30+/-10 months), group A showed a significantly lower TVR (6%) and MACCE rate (14%), compared with group B (TVR: 12%, P=0.032; MACCE: 24%, P=0.002). However, there was no difference in the rate of death, myocardial infarction, or cerebrovascular accidents between the two groups. By multivariate analysis, follow-up LDL-C level of less than 70 mg/dl was one of the significant predictors for the occurrence of MACCE (odds ratio=0.39, 95% confidence interval: 0.21-0.72, P=0.003) or TVR (odds ratio=0.39, 95% confidence interval: 0.20-0.76, P=0.005). CONCLUSION: This study showed that the attainment of LDL-C goal of less than 70 mg/dl was significantly associated with a lower MACCE or TVR rate in very high-risk Korean patients treated with DES. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 182~188 | - |
dc.relation.isPartOf | CORONARY ARTERY DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/adverse effects | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/instrumentation* | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/mortality | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cerebrovascular Disorders/etiology | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Cholesterol, LDL/blood* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Coronary Artery Disease/blood | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease/mortality | - |
dc.subject.MESH | Coronary Artery Disease/therapy* | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Guideline Adherence | - |
dc.subject.MESH | Heart Diseases/etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypolipidemic Agents/therapeutic use* | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Practice Guidelines as Topic | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Impact of the attainment of current recommended low-density lipoprotein cholesterol goal of less than 70 mg/dl on clinical outcomes in very high-risk patients treated with drug-eluting stents | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Dong Whan Kim | - |
dc.contributor.googleauthor | Seungjin Oh | - |
dc.contributor.googleauthor | Se-Jung Yoon | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Dong Woon Jeon | - |
dc.contributor.googleauthor | Joo Young Yang | - |
dc.identifier.doi | 10.1097/MCA.0b013e328337ad09 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A01512 | - |
dc.relation.journalcode | J00649 | - |
dc.identifier.eissn | 1473-5830 | - |
dc.identifier.pmid | 20168221 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019501-201005000-00009&LSLINK=80&D=ovft | - |
dc.subject.keyword | coronary artery diseases | - |
dc.subject.keyword | drug-eluting stents | - |
dc.subject.keyword | low-density lipoprotein cholesterol | - |
dc.subject.keyword | restenosis | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 182 | - |
dc.citation.endPage | 188 | - |
dc.identifier.bibliographicCitation | CORONARY ARTERY DISEASE, Vol.21(3) : 182-188, 2010 | - |
dc.identifier.rimsid | 40116 | - |
dc.type.rims | ART | - |
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