Cited 254 times in
Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS).
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T16:57:31Z | - |
dc.date.available | 2015-04-23T16:57:31Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101555 | - |
dc.description.abstract | Obesity is currently epidemic in many countries worldwide and is strongly related to diabetes and cardiovascular disease. This study investigated the differences in metabolomic profiling between overweight/obese and normal-weight men. Overweight/obese (n=30) and age-matched, normal-weight men (n=30) were included. Anthropometric parameters, conventional metabolites, and biomarkers were measured. Metabolomic profiling was analyzed with UPLC-Q-TOF MS. Overweight/obese men showed higher levels of HOMA-IR, triglycerides, total cholesterol, and LDL-cholesterol, and lower levels of HDL-cholesterol and adiponectin than lean men. Overweight/obese men showed higher proportion of stearic acid and lower proportion of oleic acid in serum phospholipids. Additionally, overweight/obese individuals showed higher fat intake and lower ratio of polyunsaturated fatty acids to saturated fatty acids. We identified three lyso-phosphatidylcholine (lysoPC) as potential plasma markers and confirmed eight known metabolites for overweight/obesity men. Especially, overweight/obese subjects showed higher levels of lysoPC C14:0 and lysoPC C18:0 and lower levels of lysoPC C18:1 than lean subjects. Results confirmed abnormal metabolism of two branched-chain amino acids, two aromatic amino acids, and fatty acid synthesis and oxidation in overweight/obese men. Additionally, the amount of dietary saturated fat may influence the proportion of saturated fatty acids in serum phospholipids and the degree of saturation of the constituent acyl group of plasma lysoPC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4368~4375 | - |
dc.relation.isPartOf | JOURNAL OF PROTEOME RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Biomarkers/chemistry | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods* | - |
dc.subject.MESH | Discriminant Analysis | - |
dc.subject.MESH | Energy Intake | - |
dc.subject.MESH | Fatty Acids/blood | - |
dc.subject.MESH | Fatty Acids/chemistry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolome | - |
dc.subject.MESH | Metabolomics/methods* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Overweight/blood* | - |
dc.subject.MESH | Phospholipids/blood | - |
dc.subject.MESH | Phospholipids/chemistry | - |
dc.subject.MESH | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods* | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Thinness/blood* | - |
dc.title | Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Ju Yeon Park | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Bo Mi Ham | - |
dc.contributor.googleauthor | Hyun-Jin Kim | - |
dc.contributor.googleauthor | Dae Young Kwon | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1021/pr100101p | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01720 | - |
dc.identifier.eissn | 1535-3907 | - |
dc.identifier.pmid | 20560578 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/pr100101p | - |
dc.subject.keyword | metabolic profiles | - |
dc.subject.keyword | obesity | - |
dc.subject.keyword | UPLC-Q-TOF MS | - |
dc.subject.keyword | lyso-phosphatidylcholine | - |
dc.subject.keyword | saturated fat | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4368 | - |
dc.citation.endPage | 4375 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PROTEOME RESEARCH, Vol.9(9) : 4368-4375, 2010 | - |
dc.identifier.rimsid | 40087 | - |
dc.type.rims | ART | - |
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