Cited 62 times in
Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis.
DC Field | Value | Language |
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dc.contributor.author | 박창욱 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2015-04-23T16:55:32Z | - |
dc.date.available | 2015-04-23T16:55:32Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101490 | - |
dc.description.abstract | BACKGROUND: Although invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well evaluated. OBJECTIVE: We investigated whether iNKT cells in patients with AD increased and whether iNKT cells were activated by thymic stromal lymphopoietin (TSLP), which is highly expressed in keratinocytes of AD. METHODS: We assessed the population of iNKT cells in PBMCs of patients with AD and healthy controls (HCs) using flow cytometry. Immunohistochemistry was used to evaluate iNKT cells and TSLP expression in AD and HC skin. We also evaluated whether iNKT cells expressed the TSLP receptor, the effects of TSLP on iNKT cells, and iNKT cell-dendritic cell interactions in a TSLP-rich environment. RESULTS: There were more iNKT cells among PBMCs of patients with moderate to severe AD than mild AD (P < .05) and HC (P < .001). The number of iNKT cells was significantly larger in severe AD skin lesions than in mild (P < .001) or moderate AD skin lesions (P < .05). TSLP expression increased in lesional skin (P < .001) but not in the sera of patients with AD (P = .729) compared with HC. iNKT cells expressed TSLP receptor protein and mRNA. TSLP directly activated iNKT cells to secrete IL-4 and IL-13, and the concurrent addition of dendritic cells further activated IFN-gamma expression. CONCLUSION: Increased iNKT cells activated by TSLP, especially in patients with severe AD, might play an essential role in the innate allergic immune response in AD. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cell Communication/immunology | - |
dc.subject.MESH | Cytokines/immunology* | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Dendritic Cells/immunology | - |
dc.subject.MESH | Dendritic Cells/pathology | - |
dc.subject.MESH | Dermatitis, Atopic/immunology* | - |
dc.subject.MESH | Dermatitis, Atopic/metabolism | - |
dc.subject.MESH | Dermatitis, Atopic/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Gene Expression Regulation/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Innate* | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphocyte Activation/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Natural Killer T-Cells/immunology* | - |
dc.subject.MESH | Natural Killer T-Cells/metabolism | - |
dc.subject.MESH | Natural Killer T-Cells/pathology | - |
dc.subject.MESH | Receptors, Cytokine/immunology | - |
dc.subject.MESH | Receptors, Cytokine/metabolism | - |
dc.subject.MESH | Skin/immunology | - |
dc.subject.MESH | Skin/metabolism | - |
dc.subject.MESH | Skin/pathology | - |
dc.title | Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Wen Hao Wu | - |
dc.contributor.googleauthor | Chang Ook Park | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Hee Jung Kim | - |
dc.contributor.googleauthor | Yeon Sook Kwon | - |
dc.contributor.googleauthor | Byung Gi Bae | - |
dc.contributor.googleauthor | Ji Yeon Noh | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.identifier.doi | 10.1016/j.jaci.2010.05.024 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01716 | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J01228 | - |
dc.identifier.eissn | 1097-6825 | - |
dc.identifier.pmid | 20624642 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0091674910008493 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | invariant natural killer T cells | - |
dc.subject.keyword | NKT cells | - |
dc.subject.keyword | thymic stromal lymphopoietin | - |
dc.subject.keyword | dendritic cells | - |
dc.contributor.alternativeName | Park, Chang Ook | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Park, Chang Ook | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 126 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 290 | - |
dc.citation.endPage | 299.e4 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.126(2) : 290-299.e4, 2010 | - |
dc.identifier.rimsid | 47766 | - |
dc.type.rims | ART | - |
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