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Increasing frequency and burden of cerebral artery atherosclerosis in Korean stroke patients

 Young Dae Kim  ;  Hye Yeon Choi  ;  Hyun Ji Cho  ;  Myoung Jin Cha  ;  Chung Mo Nam  ;  Sang Won Han  ;  Hyo Suk Nam  ;  Ji Hoe Heo 
 YONSEI MEDICAL JOURNAL, Vol.51(3) : 318-325, 2010 
Journal Title
Issue Date
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Child ; Cost of Illness* ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/physiopathology ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Intracranial Arteriosclerosis/epidemiology* ; Intracranial Arteriosclerosis/etiology ; Intracranial Arteriosclerosis/pathology ; Korea/epidemiology ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Young Adult
Cerebrovascular disorders ; atherosclerosis ; risk factors ; epidemiology
PURPOSE: Koreans have been undergoing rapid lifestyle changes that may have an effect on patterns of cerebral artery atherosclerosis. This study was aimed at determining the frequency and distribution of atherosclerosis in the cerebral arteries and associated temporal changes over the past eight-year period among Korean stroke patients. MATERIALS AND METHODS: By using stroke registry data registered between April 1999 and March 2007, we investigated the presence, severity, and location of cerebral artery atherosclerosis as determined by angiographic findings. Their annual patterns and association with vascular risk factors were investigated. RESULTS: Of 1,955 patients, 1,517 patients (77.6%) demonstrated atherosclerosis in one or more arteries. A significantly increasing trend of atherosclerosis was observed during the past eight years, which was ascribed to an increase of combined extracranial (EC) and intracranial (IC) atherosclerosis. The number of atherosclerotic arteries increased as the number of risk factors increased. In the multivariate analysis, the year and vascular risk factors were independent predictors of the presence of atherosclerosis. CONCLUSION: We found that the atherosclerotic burden has been increasing for the past eight years in Korean stroke patients, particularly the combined EC and IC subtype. Lifestyle changes and increase in vascular risk factors may be contributing factors.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Cho, Hyun Ji(조현지)
Cha, Myoung Jin(차명진)
Choi, Hye Yoen(최혜연)
Han, Sang Won(한상원)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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