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Clinical feasibility of immediate overnight switching from slow-release carbamazepine to oxcarbazepine in Korean patients with refractory partial epilepsy

Authors
 Sang-Ahm Lee  ;  Kyoung Heo  ;  Won-Joo Kim  ;  Hong-Ki Song  ;  Sung-Eun Kim  ;  Sang-Ho Kim  ;  Soon-Kee No  ;  Byung-In Lee 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.19(6) : 356-358, 2010 
Journal Title
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 
ISSN
 1059-1311 
Issue Date
2010
MeSH
Adult ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use* ; Carbamazepine/administration & dosage ; Carbamazepine/adverse effects ; Carbamazepine/analogs & derivatives* ; Carbamazepine/therapeutic use ; Delayed-Action Preparations ; Drug Resistance ; Epilepsies, Partial/drug therapy* ; Female ; Forecasting ; Humans ; Korea ; Male ; Seizures/epidemiology ; Seizures/prevention & control ; Treatment Failure
Keywords
Carbamazepine ; Oxcarbazepine ; Switching ; Partial epilepsy
Abstract
We assessed the clinical variables predicting the feasibility of immediate overnight switching from slow-release carbamazepine to oxcarbazepine in Korean patients with refractory partial epilepsy. Thirty patients aged 15 years or older with refractory partial epilepsy, who had been treated with slow-release carbamazepine as monotherapy or in combination therapy, were switched overnight from slow-release carbamazepine (mean dose at switching, 900 mg/day) to oxcarbazepine. Of these 30 patients, 29 (96.7%) had been treated with a slow-release formulation of carbamazepine. The proportion of patients with polytherapy was 85.3%. Overall, 9 of 30 (30%) switched patients experienced clinically significant adverse events until 2 weeks after switching, including 2 with seizure aggravation. The only clinical variable related to the failure of overnight switching was the number of seizures at baseline
Full Text
http://www.sciencedirect.com/science/article/pii/S1059131110001068
DOI
10.1016/j.seizure.2010.05.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Lee, Byung In(이병인)
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101402
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