316 259

Cited 0 times in

Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author김종찬-
dc.contributor.author심재광-
dc.contributor.author최용선-
dc.date.accessioned2015-04-23T16:52:29Z-
dc.date.available2015-04-23T16:52:29Z-
dc.date.issued2010-
dc.identifier.issn0375-9393-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101392-
dc.description.abstractAIM: This prospective, randomized and controlled trial compares the use of human albumin (HA) and hydroxyethyl starch (HES) 130/0.4 in the priming solution for a non-biocompatible cardiopulmonary bypass (CPB) circuit. The effects of each substance on coagulation, postoperative blood loss and pro-inflammatory activities were examined. METHODS: Thirty-six adult patients undergoing mitral valvular heart surgery were randomly assigned to either the HA or HES group; 500 mL of 5% HA or 6% HES 130/0.4 were added to the priming solution of the CPB circuit for each group, respectively. Coagulation variables were measured perioperatively; these variables included thromboelastographic (TEG) parameters and pro-inflammatory markers such as interleukin (IL)-6, IL-8 and tumor necrotic factor (TNF)-a. Postoperative blood loss and transfusion requirements were also assessed. RESULTS: There were no significant intergroup differences in the coagulation variables (including TEG parameters), serum concentrations of IL-6, IL-8 and TNF-a, and blood loss or transfusion requirements. TEG parameters, which indicate the speed of solid clot formation and the strength of the fibrin clot, decreased up to 4 hours after CPB in both groups. Serum concentrations of IL-6, IL-8 and TNF-a were higher up to 12 hours after surgery compared to baseline values in both groups. Hemoglobin levels and platelet counts were lower up to 12 hours after surgery compared to baseline values in both groups. CONCLUSION: HES 130/0.4 was comparable to albumin as a component of the priming solution for a non-biocompatible CPB circuit. The two substances showed similar effects on coagulation variables, blood loss and pro-inflammatory activities in adult patients undergoing mitral valvular heart surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent584~591-
dc.relation.isPartOfMINERVA ANESTESIOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlood Coagulation/drug effects*-
dc.subject.MESHCardiopulmonary Bypass*-
dc.subject.MESHFemale-
dc.subject.MESHGlycoproteins/administration & dosage*-
dc.subject.MESHHeart Valve Diseases/surgery-
dc.subject.MESHHumans-
dc.subject.MESHHydroxyethyl Starch Derivatives/administration & dosage*-
dc.subject.MESHInflammation/immunology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitral Valve-
dc.subject.MESHPlasma Substitutes/administration & dosage*-
dc.subject.MESHPostoperative Hemorrhage/epidemiology*-
dc.subject.MESHProspective Studies-
dc.subject.MESHSerum Albumin/administration & dosage*-
dc.subject.MESHSerum Albumin, Human-
dc.titleComparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorY. S. Choi-
dc.contributor.googleauthorJ. K. Shim-
dc.contributor.googleauthorW. W. Hong-
dc.contributor.googleauthorJ. C. Kim-
dc.contributor.googleauthorY. L .Kwak-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02205-
dc.contributor.localIdA04119-
dc.contributor.localIdA00929-
dc.relation.journalcodeJ02235-
dc.identifier.eissn1827-1596-
dc.identifier.pmid20661198-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKim, Jong Chan-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorKim, Jong Chan-
dc.citation.volume76-
dc.citation.number8-
dc.citation.startPage584-
dc.citation.endPage591-
dc.identifier.bibliographicCitationMINERVA ANESTESIOLOGICA, Vol.76(8) : 584-591, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.