Cited 27 times in
APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T16:52:26Z | - |
dc.date.available | 2015-04-23T16:52:26Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101390 | - |
dc.description.abstract | OBJECTIVE: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. METHODS: Hypertriglyceridemia patients (TG, 150-500mg/dL, n=283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). RESULTS: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/T) for the T allele had lower serum TG (P=0.009) and higher HDL cholesterol (P=0.036) than other subjects. In T/T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1=-0.29, P=0.05, r2=-0.28, P<0.1) and positively correlated with changes in HDL cholesterol (r1=0.30, P<0.05, r2=0.32, P<0.05) and free fatty acid (r1=0.38, P<0.01, r2=0.40, P<0.01). In those with moderate hypertriglyceridemia (TG, 200-500mg/dL, n=130), APOA5-1131T/T carriers achieved significantly lower TG (P=0.007) and higher HDL cholesterol (P<0.001) than -1131C allele carriers. Additionally, statistically significant interactions between the -1131T>C and the compliance of DIRE were found for the change in TG (P=0.002) and HDL cholesterol (P=0.039). In good compliance group, T/T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. CONCLUSIONS: APOA5-1131T/T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 512~519 | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anthropometry | - |
dc.subject.MESH | Apolipoprotein A-V | - |
dc.subject.MESH | Apolipoproteins A/blood* | - |
dc.subject.MESH | Apolipoproteins A/genetics* | - |
dc.subject.MESH | Cholesterol/metabolism | - |
dc.subject.MESH | Cholesterol, HDL/metabolism | - |
dc.subject.MESH | Diet* | - |
dc.subject.MESH | Exercise* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertriglyceridemia/diet therapy* | - |
dc.subject.MESH | Hypertriglyceridemia/genetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Triglycerides/metabolism* | - |
dc.title | APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Hey Jun Park | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Sang-Hyun Lee | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2010.03.014 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 20392444 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915010002303 | - |
dc.subject.keyword | APOA5-1131 T>C | - |
dc.subject.keyword | Dietary intervention and regular exercise | - |
dc.subject.keyword | Triglycerides | - |
dc.subject.keyword | Hypertriglyceridemia | - |
dc.subject.keyword | Apolipoprotein A5 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 211 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 512 | - |
dc.citation.endPage | 519 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.211(2) : 512-519, 2010 | - |
dc.identifier.rimsid | 51021 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.