Cited 11 times in
Prospective validation of P2/MS noninvasive index using complete blood counts for detecting oesophageal varices in B-viral cirrhosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 백용한 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2015-04-23T16:51:40Z | - |
dc.date.available | 2015-04-23T16:51:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101365 | - |
dc.description.abstract | BACKGROUNDS: Periodic endoscopic screening for oesophageal varices (OVs) and prophylactic treatment for high-risk OVs (HOVs; medium/large OVs or small OVs plus red sign/decompensation) are currently recommended for all cirrhotic patients. However, if a simple, noninvasive test is available, many low-risk patients may reliably avoid endoscopy. AIMS: We conducted a large-scale validation study of a simple, noninvasive test called P2/MS based on complete blood counts, (platelet count)(2)/[monocyte fraction (%) x segmented neutrophil fraction (%)], and compared it with other predictive tests for HOVs in B-viral cirrhotic patients. METHODS: From 2008 to 2009, we prospectively enrolled 318 consecutive B-viral cirrhotic patients. All underwent endoscopy and laboratory evaluation. RESULTS: An area under the receiver operating characteristic curve of P2/MS was 0.941 for HOVs, comparable with those of the age-spleen platelet ratio index (0.922, P=0.317) and spleen-platelet ratio index (0.922, P=0.324), and better than those of age-platelet index (0.653, P<0.001), aspartate aminotransferase (AST)-platelet ratio index (0.871, P<0.006) and AST-alanine aminotransferase ratio (0.644, P<0.001). P2/MS<11 reliably identified 83 patients as having HOVs (94.0% positive predictive value), while at a cutoff of 25 and 179 as not having HOVs (94.4% negative predictive value). Overall, P2/MS reliably determined the likelihood of HOVs in 262 patients (82.4%). These cutoffs were validated internally using bootstrap resampling methods, which showed good agreement. CONCLUSIONS: P2/MS is a simple, accurate and economical method, reducing the need for endoscopy in B-viral cirrhosis. Patients with P2/MS<11 should be considered for appropriate prophylactic treatments, while those with P2/MS>25 may avoid endoscopy reliably | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 860~866 | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alanine Transaminase/blood | - |
dc.subject.MESH | Aspartate Aminotransferases/blood | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Endoscopy | - |
dc.subject.MESH | Esophageal and Gastric Varices/blood | - |
dc.subject.MESH | Esophageal and Gastric Varices/diagnosis* | - |
dc.subject.MESH | Esophageal and Gastric Varices/virology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocyte Count* | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Liver Cirrhosis/blood | - |
dc.subject.MESH | Liver Cirrhosis/virology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes | - |
dc.subject.MESH | Neutrophils | - |
dc.subject.MESH | Platelet Count* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Spleen/diagnostic imaging | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | Prospective validation of P2/MS noninvasive index using complete blood counts for detecting oesophageal varices in B-viral cirrhosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Yong Han Paik | - |
dc.contributor.googleauthor | Kwan Sik Lee | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.identifier.doi | 10.1111/j.1478-3231.2010.02260.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A01829 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 20492515 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02260.x/abstract | - |
dc.subject.keyword | cirrhosis | - |
dc.subject.keyword | endoscopy | - |
dc.subject.keyword | oesophageal varix | - |
dc.subject.keyword | P2/MS | - |
dc.subject.keyword | prediction | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Paik, Yong Han | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 30 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 860 | - |
dc.citation.endPage | 866 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.30(6) : 860-866, 2010 | - |
dc.identifier.rimsid | 51008 | - |
dc.type.rims | ART | - |
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