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Prospective validation of P2/MS noninvasive index using complete blood counts for detecting oesophageal varices in B-viral cirrhosis

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김자경-
dc.contributor.author박준용-
dc.contributor.author백용한-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.date.accessioned2015-04-23T16:51:40Z-
dc.date.available2015-04-23T16:51:40Z-
dc.date.issued2010-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101365-
dc.description.abstractBACKGROUNDS: Periodic endoscopic screening for oesophageal varices (OVs) and prophylactic treatment for high-risk OVs (HOVs; medium/large OVs or small OVs plus red sign/decompensation) are currently recommended for all cirrhotic patients. However, if a simple, noninvasive test is available, many low-risk patients may reliably avoid endoscopy. AIMS: We conducted a large-scale validation study of a simple, noninvasive test called P2/MS based on complete blood counts, (platelet count)(2)/[monocyte fraction (%) x segmented neutrophil fraction (%)], and compared it with other predictive tests for HOVs in B-viral cirrhotic patients. METHODS: From 2008 to 2009, we prospectively enrolled 318 consecutive B-viral cirrhotic patients. All underwent endoscopy and laboratory evaluation. RESULTS: An area under the receiver operating characteristic curve of P2/MS was 0.941 for HOVs, comparable with those of the age-spleen platelet ratio index (0.922, P=0.317) and spleen-platelet ratio index (0.922, P=0.324), and better than those of age-platelet index (0.653, P<0.001), aspartate aminotransferase (AST)-platelet ratio index (0.871, P<0.006) and AST-alanine aminotransferase ratio (0.644, P<0.001). P2/MS<11 reliably identified 83 patients as having HOVs (94.0% positive predictive value), while at a cutoff of 25 and 179 as not having HOVs (94.4% negative predictive value). Overall, P2/MS reliably determined the likelihood of HOVs in 262 patients (82.4%). These cutoffs were validated internally using bootstrap resampling methods, which showed good agreement. CONCLUSIONS: P2/MS is a simple, accurate and economical method, reducing the need for endoscopy in B-viral cirrhosis. Patients with P2/MS<11 should be considered for appropriate prophylactic treatments, while those with P2/MS>25 may avoid endoscopy reliably-
dc.description.statementOfResponsibilityopen-
dc.format.extent860~866-
dc.relation.isPartOfLIVER INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlanine Transaminase/blood-
dc.subject.MESHAspartate Aminotransferases/blood-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiopsy-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHEndoscopy-
dc.subject.MESHEsophageal and Gastric Varices/blood-
dc.subject.MESHEsophageal and Gastric Varices/diagnosis*-
dc.subject.MESHEsophageal and Gastric Varices/virology-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLeukocyte Count*-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Cirrhosis/blood-
dc.subject.MESHLiver Cirrhosis/virology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonocytes-
dc.subject.MESHNeutrophils-
dc.subject.MESHPlatelet Count*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSpleen/diagnostic imaging-
dc.subject.MESHUltrasonography-
dc.titleProspective validation of P2/MS noninvasive index using complete blood counts for detecting oesophageal varices in B-viral cirrhosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorYong Han Paik-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorDo Young Kim-
dc.identifier.doi10.1111/j.1478-3231.2010.02260.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00487-
dc.contributor.localIdA00852-
dc.contributor.localIdA01675-
dc.contributor.localIdA01829-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02171-
dc.identifier.eissn1478-3231-
dc.identifier.pmid20492515-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02260.x/abstract-
dc.subject.keywordcirrhosis-
dc.subject.keywordendoscopy-
dc.subject.keywordoesophageal varix-
dc.subject.keywordP2/MS-
dc.subject.keywordprediction-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNamePaik, Yong Han-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorPaik, Yong Han-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume30-
dc.citation.number6-
dc.citation.startPage860-
dc.citation.endPage866-
dc.identifier.bibliographicCitationLIVER INTERNATIONAL, Vol.30(6) : 860-866, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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