Cited 24 times in
Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2015-04-23T16:49:38Z | - |
dc.date.available | 2015-04-23T16:49:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101302 | - |
dc.description.abstract | BACKGROUND: Whether low-molecular-weight heparin (LMWH) is superior to unfractionated heparin (UFH) in acute ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) remains unclear. METHODS: A total of 3,372 STEMI patients who underwent primary PCI with DESs received either LMWH (n = 1,531 patients, subcutaneous enoxaparin 1 mg/kg, bid for 3-5 days plus reduced dose of UFH [50 U/kg] during PCI) or UFH alone (n = 1,841 patients, intravenous bolus injection of 5,000 U, followed by 24,000 U/d infusion for at least 48 hours). The bleeding events and clinical outcomes during in-hospital and at 8 months were compared. RESULTS: The incidences of major and minor bleeding events were similar between the 2 groups. Multivariable Cox regression analysis showed that LMWH group had lower incidences of cardiac death (adjusted odds ratio [OR] 0.55, 95% CI 0.39-0.77, P < .001), total death (adjusted OR 0.50, 95% CI 0.37-0.68, P < .001), and total major adverse cardiac events (adjusted OR 0.77, 95% CI 0.62-0.95, P = .017) at 8 months as compared with UFH group. Similar results were obtained across different subgroups including different DESs, age, and sex. CONCLUSIONS: The LMWH enoxaparin combined with reduced dose of UFH (50 U/kg) administration as an adjunctive antithrombotic therapy in STEMI patients undergoing primary PCI with DESs seems to be safe and efficacious. However, randomized clinical trials are needed to confirm this conclusion. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary* | - |
dc.subject.MESH | Anticoagulants/administration & dosage* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drug-Eluting Stents | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Enoxaparin/administration & dosage* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/drug therapy | - |
dc.subject.MESH | Myocardial Infarction/therapy* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong-Jian Li | - |
dc.contributor.googleauthor | Seung-Woon Rha | - |
dc.contributor.googleauthor | Kang-Yin Chen | - |
dc.contributor.googleauthor | Kanhaiya L. Poddar | - |
dc.contributor.googleauthor | Zhe Jin | - |
dc.contributor.googleauthor | Yoshiyasu Minami | - |
dc.contributor.googleauthor | Lin Wang | - |
dc.contributor.googleauthor | Qun Dang | - |
dc.contributor.googleauthor | Guang-Ping Li | - |
dc.contributor.googleauthor | Sureshkumar Ramasamy | - |
dc.contributor.googleauthor | Ji-Young Park | - |
dc.contributor.googleauthor | Chol Ung Choi | - |
dc.contributor.googleauthor | Jin-Won Kim | - |
dc.contributor.googleauthor | Eung Ju Kim | - |
dc.contributor.googleauthor | 'Chang Gyu Park | - |
dc.contributor.googleauthor | Hong Seog Seo | - |
dc.contributor.googleauthor | Dong Joo Oh | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Young Keun Ahn | - |
dc.contributor.googleauthor | Taek Jong Hong | - |
dc.contributor.googleauthor | Jong-Seon Park | - |
dc.contributor.googleauthor | Young Jo Kim | - |
dc.contributor.googleauthor | Seung Ho Hur | - |
dc.contributor.googleauthor | In Whan Seong | - |
dc.contributor.googleauthor | Jei Keon Chae | - |
dc.contributor.googleauthor | Myeong Chan Cho | - |
dc.contributor.googleauthor | Jang Ho Bae | - |
dc.contributor.googleauthor | Dong Hoon Choi | - |
dc.contributor.googleauthor | Yang Soo Jang | - |
dc.contributor.googleauthor | In Ho Chae | - |
dc.contributor.googleauthor | Hyo Soo Kim | - |
dc.contributor.googleauthor | Chong Jin Kim | - |
dc.contributor.googleauthor | Jung Han Yoon | - |
dc.contributor.googleauthor | Tae Hoon Ahn | - |
dc.contributor.googleauthor | Seung-Jea Tahk | - |
dc.contributor.googleauthor | Wook Sung Chung | - |
dc.contributor.googleauthor | Ki Bae Seung | - |
dc.contributor.googleauthor | Seung Jung Park | - |
dc.identifier.doi | 10.1016/j.ahj.2009.12.041 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00069 | - |
dc.identifier.eissn | 1097-6744 | - |
dc.identifier.pmid | 20362730 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0002870310000888 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.citation.volume | 159 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 684 | - |
dc.citation.endPage | 690.e1 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, Vol.159(4) : 684-690.e1, 2010 | - |
dc.identifier.rimsid | 49422 | - |
dc.type.rims | ART | - |
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