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The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis

DC FieldValueLanguage
dc.contributor.author김혜연-
dc.contributor.author서석교-
dc.contributor.author양효인-
dc.contributor.author이경은-
dc.contributor.author이병석-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2015-04-23T16:49:07Z-
dc.date.available2015-04-23T16:49:07Z-
dc.date.issued2010-
dc.identifier.issn0268-1161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101285-
dc.description.abstractBACKGROUND: Oxidative stress is considered to be involved in the establishment and development of endometriosis. Thioredoxin (TRX) is an endogenous redox regulator that protects cells against oxidative stress, and TRX-binding protein-2 (TBP-2) is a negative regulator of TRX in the biological function and expression. The aim of this study was to investigate the roles of TRX and TBP-2 in the pathophysiology of endometriosis. METHODS: A total of 35 patients with histologically confirmed endometriosis and 31 patients without endometriosis participated in this study. Real-time polymerase chain reaction was used to quantify TRX and TBP-2 mRNA levels, and immunohistochemistry (IHC) was used to assess TRX and TBP-2 protein localization in the endometrium. Serum and peritoneal fluid levels of TRX and TBP-2 were measured using a specific commercial ELISA. RESULTS: There were no significant differences in TRX mRNA levels in the endometrium of patients with endometriosis and the control groups. However, TBP-2 mRNA levels in the endometrium were lower, and the TRX to TBP-2 ratio was higher in patients with endometriosis than in the control group. In particular, the TRX to TBP-2 ratio was significantly higher during late secretory and menstrual phase in patients with endometriosis compared with the control group. IHC studies also showed the decreased TBP-2 immunoreactivity in patients with endometriosis compared with the control group. There was no correlation between TRX and TBP-2 mRNA levels in patients with endometriosis, whereas TRX mRNA levels were positively correlated with TBP-2 mRNA levels in the control group. There were no significant differences between the two groups in TRX and TBP-2 levels in serum or peritoneal fluid. CONCLUSIONS: Aberrant expression of TRX and TBP-2 in the endometrium may be associated with the establishment of endometriosis-
dc.description.statementOfResponsibilityopen-
dc.format.extent1251~1258-
dc.relation.isPartOfHUMAN REPRODUCTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAscitic Fluid/metabolism-
dc.subject.MESHBase Sequence-
dc.subject.MESHCarrier Proteins/blood-
dc.subject.MESHCarrier Proteins/genetics*-
dc.subject.MESHCarrier Proteins/metabolism*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDNA Primers/genetics-
dc.subject.MESHEndometriosis/etiology-
dc.subject.MESHEndometriosis/genetics*-
dc.subject.MESHEndometriosis/metabolism*-
dc.subject.MESHEndometrium/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHThioredoxins/blood-
dc.subject.MESHThioredoxins/genetics*-
dc.subject.MESHThioredoxins/metabolism*-
dc.subject.MESHYoung Adult-
dc.titleThe roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorHyo In Yang-
dc.contributor.googleauthorKyung Eun Lee-
dc.contributor.googleauthorHye Yeon Kim-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi10.1093/humrep/deq027-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01174-
dc.contributor.localIdA01888-
dc.contributor.localIdA02329-
dc.contributor.localIdA02795-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.contributor.localIdA02650-
dc.relation.journalcodeJ01013-
dc.identifier.eissn1460-2350-
dc.identifier.pmid20172870-
dc.contributor.alternativeNameKim, Hye Yeon-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameYang, Hyo In-
dc.contributor.alternativeNameLee, Kyung Eun-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.alternativeNameChoi, Young Sik-
dc.contributor.affiliatedAuthorKim, Hye Yeon-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorYang, Hyo In-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.contributor.affiliatedAuthorChoi, Young Sik-
dc.contributor.affiliatedAuthorLee, Kyung Eun-
dc.citation.volume25-
dc.citation.number5-
dc.citation.startPage1251-
dc.citation.endPage1258-
dc.identifier.bibliographicCitationHUMAN REPRODUCTION, Vol.25(5) : 1251-1258, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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