Cited 17 times in
The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis
DC Field | Value | Language |
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dc.contributor.author | 김혜연 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 양효인 | - |
dc.contributor.author | 이경은 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2015-04-23T16:49:07Z | - |
dc.date.available | 2015-04-23T16:49:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0268-1161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101285 | - |
dc.description.abstract | BACKGROUND: Oxidative stress is considered to be involved in the establishment and development of endometriosis. Thioredoxin (TRX) is an endogenous redox regulator that protects cells against oxidative stress, and TRX-binding protein-2 (TBP-2) is a negative regulator of TRX in the biological function and expression. The aim of this study was to investigate the roles of TRX and TBP-2 in the pathophysiology of endometriosis. METHODS: A total of 35 patients with histologically confirmed endometriosis and 31 patients without endometriosis participated in this study. Real-time polymerase chain reaction was used to quantify TRX and TBP-2 mRNA levels, and immunohistochemistry (IHC) was used to assess TRX and TBP-2 protein localization in the endometrium. Serum and peritoneal fluid levels of TRX and TBP-2 were measured using a specific commercial ELISA. RESULTS: There were no significant differences in TRX mRNA levels in the endometrium of patients with endometriosis and the control groups. However, TBP-2 mRNA levels in the endometrium were lower, and the TRX to TBP-2 ratio was higher in patients with endometriosis than in the control group. In particular, the TRX to TBP-2 ratio was significantly higher during late secretory and menstrual phase in patients with endometriosis compared with the control group. IHC studies also showed the decreased TBP-2 immunoreactivity in patients with endometriosis compared with the control group. There was no correlation between TRX and TBP-2 mRNA levels in patients with endometriosis, whereas TRX mRNA levels were positively correlated with TBP-2 mRNA levels in the control group. There were no significant differences between the two groups in TRX and TBP-2 levels in serum or peritoneal fluid. CONCLUSIONS: Aberrant expression of TRX and TBP-2 in the endometrium may be associated with the establishment of endometriosis | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1251~1258 | - |
dc.relation.isPartOf | HUMAN REPRODUCTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Ascitic Fluid/metabolism | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Carrier Proteins/blood | - |
dc.subject.MESH | Carrier Proteins/genetics* | - |
dc.subject.MESH | Carrier Proteins/metabolism* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | DNA Primers/genetics | - |
dc.subject.MESH | Endometriosis/etiology | - |
dc.subject.MESH | Endometriosis/genetics* | - |
dc.subject.MESH | Endometriosis/metabolism* | - |
dc.subject.MESH | Endometrium/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Thioredoxins/blood | - |
dc.subject.MESH | Thioredoxins/genetics* | - |
dc.subject.MESH | Thioredoxins/metabolism* | - |
dc.subject.MESH | Young Adult | - |
dc.title | The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Hyo In Yang | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 10.1093/humrep/deq027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02329 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.contributor.localId | A02650 | - |
dc.relation.journalcode | J01013 | - |
dc.identifier.eissn | 1460-2350 | - |
dc.identifier.pmid | 20172870 | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yang, Hyo In | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Eun | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1251 | - |
dc.citation.endPage | 1258 | - |
dc.identifier.bibliographicCitation | HUMAN REPRODUCTION, Vol.25(5) : 1251-1258, 2010 | - |
dc.identifier.rimsid | 49411 | - |
dc.type.rims | ART | - |
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