Cited 11 times in
Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-04-23T16:49:04Z | - |
dc.date.available | 2015-04-23T16:49:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101283 | - |
dc.description.abstract | We report two childhood cases of acute leukemia with t(16;21)(p11.2;q22) and FUS-ERG rearrangements. Patient 1 (14 years old) was initially diagnosed with acute myeloid leukemia. Chromosome study showed a t(16;21)(p11.2;q22) clone in more than one third of the cells analyzed, and further investigation with reverse-transcriptase polymerase chain reaction, cloning, and sequencing confirmed FUS-ERG rearrangement (type B). Patient 2 (8 months old) was diagnosed with acute lymphoblastic leukemia (ALL) on the basis of bone marrow morphology and immunophenotyping. Chromosome study revealed a 45,XY,-16,der(21)t(16;21)(p11.2;q22) in 50% of the cells analyzed. Further studies for the detection of a FUS-ERG chimeric transcript were conducted, and an unusual type of FUS-ERG rearrangement was discovered, which has been reported in only three patients including a 1-year-old infant with ALL. Although more clinical studies are necessary, we believe that a possible association between ALL and a specific type of FUS-ERG fusion transcript might be considered, especially in childhood cases with t(16;21). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 180~183 | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Chromosomes, Human, Pair 16* | - |
dc.subject.MESH | Chromosomes, Human, Pair 21* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oncogene Proteins, Fusion/genetics* | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics* | - |
dc.subject.MESH | RNA, Messenger/analysis* | - |
dc.subject.MESH | RNA-Binding Protein FUS/genetics* | - |
dc.subject.MESH | Translocation, Genetic* | - |
dc.title | Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Seung Hwan Oh | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Sanggyu Lee | - |
dc.contributor.googleauthor | Sun Young Cho | - |
dc.contributor.googleauthor | So Young Kim | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Ji Kyoung Park | - |
dc.contributor.googleauthor | Sae Am Song | - |
dc.contributor.googleauthor | Ja Young Lee | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Hye Ran Kim | - |
dc.contributor.googleauthor | Jeong Nyeo Lee | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2010.04.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 20620604 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460810001603 | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.citation.volume | 200 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 180 | - |
dc.citation.endPage | 183 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.200(2) : 180-183, 2010 | - |
dc.identifier.rimsid | 49409 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.