Cited 12 times in
Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians
DC Field | Value | Language |
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dc.contributor.author | 이경아 | - |
dc.date.accessioned | 2015-04-23T16:47:04Z | - |
dc.date.available | 2015-04-23T16:47:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101219 | - |
dc.description.abstract | Background: Although a number of association studies of gastric cancer (GC) risk have been conducted worldwide, their results have been inconsistent among different populations. The association between GC incidence and Helicobacter pylori (H. pylori) infection is somewhat of an enigma that has yet to be clearly explained. Geographically-restricted positive selection due to unique environmental pressures often result in large allele frequency differences between populations. Thus, population differences need to be investigated when attempting to identify genes that contribute to phenotypes that differ greatly between populations. Methods: We analyzed population differences in 18 polymorphisms of 12 GC-associated or immune response-related genes from 3 ethnic groups comprising 50 Koreans, 46 Indians, and 60 Caucasians; these groups differed in H. pylori seropositivity and susceptibility to GC. Results: An interleukin 10 (IL10) polymorphism demonstrated a significantly different genotype distribution (F(ST)=0.306, P=0.014), indicating a large difference between the Korean and Caucasian populations. The odds ratio of IL10 polymorphism allele between the populations was 38.32 (95% confidence interval, 11.49-127.83). Conclusion: This finding, taken together with previous evidence, provides a possible explanation for previous discrepant association results and supports the idea that IL10 gene polymorphisms can differentially affect GC development among populations. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~77 | - |
dc.language | CYTOKINE | - |
dc.publisher | CYTOKINE | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | European Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Gene Frequency/genetics | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | India/ethnology | - |
dc.subject.MESH | Interleukin-10/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics | - |
dc.subject.MESH | Republic of Korea/ethnology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.title | Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hong-Hee Won | - |
dc.contributor.googleauthor | Jong-Won Kim | - |
dc.contributor.googleauthor | Min-Ji Kim | - |
dc.contributor.googleauthor | Seonwoo Kim | - |
dc.contributor.googleauthor | Jun-Hee Park | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.identifier.doi | 10.1016/j.cyto.2010.03.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02647 | - |
dc.relation.journalcode | J00691 | - |
dc.identifier.eissn | 1096-0023 | - |
dc.identifier.pmid | 20363151 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1043466610000682 | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.citation.volume | 51 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | CYTOKINE, Vol.51(1) : 73-77, 2010 | - |
dc.identifier.rimsid | 52139 | - |
dc.type.rims | ART | - |
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