Cited 9 times in
The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: serial transcranial Doppler studies
DC Field | Value | Language |
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dc.contributor.author | 이경열 | - |
dc.contributor.author | 이필휴 | - |
dc.date.accessioned | 2015-04-23T16:45:38Z | - |
dc.date.available | 2015-04-23T16:45:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101174 | - |
dc.description.abstract | Levodopa treatment in patients with Parkinson's disease (PD) is known to cause elevation in serum homocysteine levels. We investigated whether this increase in homocysteine level influences cerebral vascular flow velocity and resistance using transcranial Doppler (TCD). This study included 17 patients with de novo PD. Homocysteine levels and TCD parameters at middle cerebral artery were investigated before and after 3 months of levodopa treatment. Correlation analyses were done between changes in homocysteine levels and TCD parameters. After 3 months of levodopa treatment, homocysteine level increased significantly from 13.3mg/dL to 17.0 mg/dL (p < 0.001), but there were no meaningful changes in mean velocity (MV) and pulsatility index (PI). Correlation analysis revealed that the changes in homocysteine level had negative correlation with MV (r = -0.53, p = 0.027) and positive correlation with PI (r = 0.55, p = 0.028). Our study infer that although short-term treatment of levodopa itself does not cause overall alteration of cerebral blood flow velocities and resistances, patients who has greater degree of increased homocysteine level may still be at a risk of developing cerebral vascular stiffness | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 225~227 | - |
dc.relation.isPartOf | PARKINSONISM & RELATED DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antiparkinson Agents/pharmacology | - |
dc.subject.MESH | Antiparkinson Agents/therapeutic use* | - |
dc.subject.MESH | Cerebrovascular Circulation/drug effects* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodynamics/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Levodopa/pharmacology | - |
dc.subject.MESH | Levodopa/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parkinsonian Disorders/diagnostic imaging | - |
dc.subject.MESH | Parkinsonian Disorders/drug therapy* | - |
dc.subject.MESH | Parkinsonian Disorders/physiopathology* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Ultrasonography, Doppler, Transcranial/methods | - |
dc.title | The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: serial transcranial Doppler studies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Seok Woo Yong | - |
dc.contributor.googleauthor | Kyung Yul Lee | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1016/j.parkreldis.2009.09.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A03270 | - |
dc.relation.journalcode | J02468 | - |
dc.identifier.eissn | 1873-5126 | - |
dc.identifier.pmid | 19815447 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1353802009002259 | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | PARKINSONISM & RELATED DISORDERS, Vol.16(3) : 225-227, 2010 | - |
dc.identifier.rimsid | 52114 | - |
dc.type.rims | ART | - |
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