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The independent effects of cigarette smoking, alcohol consumption, and serum aspartate aminotransferase on the alanine aminotransferase ratio in korean men for the risk for esophageal cancer

DC FieldValueLanguage
dc.contributor.author김희진-
dc.contributor.author지선하-
dc.date.accessioned2015-04-23T16:43:25Z-
dc.date.available2015-04-23T16:43:25Z-
dc.date.issued2010-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101104-
dc.description.abstractPURPOSE: The goal of this study is to assess the interactions among alcohol consumption, cigarette smoking, and aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratios on esophageal cancer. MATERIALS AND METHODS: Alcohol and the risk of incidence and death from esophageal cancer were examined in a 14-year prospective cohort study of 782,632 Korean men, 30 to 93 years of age, who received health insurance from the National Health Insurance Corporation and had a medical evaluation from 1992 to 1995. RESULTS: Smoking, alcohol intake, and AST/ALT ratios were associated with the increased risk of esophageal cancer in a dose-dependent manner independent of each other. Smoking was associated with an increased risk of incidence [Hazard ratio (HR) = 2.2, 95% CI = 1.8 to 2.5] and mortality (HR = 2.5, 2.0 to 3.1). Combined HR of incidence for alcohol consumption (> 25 g/day) and smoking was 4.5 (3.8-5.5); for alcohol (> 25 g/day) and the AST/ALT ratio (>or= 2.0), it was 5.8 (4.6-7.2); for smoking and the AST/ALT ratio (>or= 2.0), it was 6.3 (5.1-7.5). Similar results were seen for mortality from esophageal cancer. Subjects who drank >or= 25 g/day with an AST/ALT ratio >or= 2 had a higher risk of esophageal cancer incidence (HR = 6.5, 4.8 to 8.7) compared with those who drank >or= 25 g/day with an AST/ALT ratio < 2 (HR = 2.2, 1.9 to 2.6). CONCLUSION: Alcohol, smoking, and the AST/ALT ratio are independently associated with increased risk of esophageal cancer but did not interact synergistically. The combination of the AST/ALT ratio with a questionnaire for alcohol consumption may increase the effectiveness for determining the risk of esophageal cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent310~317-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlanine Transaminase/blood*-
dc.subject.MESHAlcohol Drinking/adverse effects*-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHAspartate Aminotransferases/blood*-
dc.subject.MESHEsophageal Neoplasms/enzymology*-
dc.subject.MESHEsophageal Neoplasms/epidemiology*-
dc.subject.MESHEsophageal Neoplasms/etiology-
dc.subject.MESHHumans-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHSmoking/adverse effects*-
dc.titleThe independent effects of cigarette smoking, alcohol consumption, and serum aspartate aminotransferase on the alanine aminotransferase ratio in korean men for the risk for esophageal cancer-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorHeejin Kimm-
dc.contributor.googleauthorSangwon Kim-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.3349/ymj.2010.51.3.310-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01226-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid20376881-
dc.subject.keywordAlcohol-
dc.subject.keywordsmoking-
dc.subject.keywordalanine transaminase-
dc.subject.keywordaspartate aminotransferases-
dc.subject.keywordesophageal neoplasms-
dc.contributor.alternativeNameKimm, Hee Jin-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorKimm, Hee Jin-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume51-
dc.citation.number3-
dc.citation.startPage310-
dc.citation.endPage317-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.51(3) : 310-317, 2010-
dc.identifier.rimsid50833-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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