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The independent effects of cigarette smoking, alcohol consumption, and serum aspartate aminotransferase on the alanine aminotransferase ratio in korean men for the risk for esophageal cancer
DC Field | Value | Language |
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dc.contributor.author | 김희진 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-04-23T16:43:25Z | - |
dc.date.available | 2015-04-23T16:43:25Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101104 | - |
dc.description.abstract | PURPOSE: The goal of this study is to assess the interactions among alcohol consumption, cigarette smoking, and aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratios on esophageal cancer. MATERIALS AND METHODS: Alcohol and the risk of incidence and death from esophageal cancer were examined in a 14-year prospective cohort study of 782,632 Korean men, 30 to 93 years of age, who received health insurance from the National Health Insurance Corporation and had a medical evaluation from 1992 to 1995. RESULTS: Smoking, alcohol intake, and AST/ALT ratios were associated with the increased risk of esophageal cancer in a dose-dependent manner independent of each other. Smoking was associated with an increased risk of incidence [Hazard ratio (HR) = 2.2, 95% CI = 1.8 to 2.5] and mortality (HR = 2.5, 2.0 to 3.1). Combined HR of incidence for alcohol consumption (> 25 g/day) and smoking was 4.5 (3.8-5.5); for alcohol (> 25 g/day) and the AST/ALT ratio (>or= 2.0), it was 5.8 (4.6-7.2); for smoking and the AST/ALT ratio (>or= 2.0), it was 6.3 (5.1-7.5). Similar results were seen for mortality from esophageal cancer. Subjects who drank >or= 25 g/day with an AST/ALT ratio >or= 2 had a higher risk of esophageal cancer incidence (HR = 6.5, 4.8 to 8.7) compared with those who drank >or= 25 g/day with an AST/ALT ratio < 2 (HR = 2.2, 1.9 to 2.6). CONCLUSION: Alcohol, smoking, and the AST/ALT ratio are independently associated with increased risk of esophageal cancer but did not interact synergistically. The combination of the AST/ALT ratio with a questionnaire for alcohol consumption may increase the effectiveness for determining the risk of esophageal cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 310~317 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Alanine Transaminase/blood* | - |
dc.subject.MESH | Alcohol Drinking/adverse effects* | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Aspartate Aminotransferases/blood* | - |
dc.subject.MESH | Esophageal Neoplasms/enzymology* | - |
dc.subject.MESH | Esophageal Neoplasms/epidemiology* | - |
dc.subject.MESH | Esophageal Neoplasms/etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Smoking/adverse effects* | - |
dc.title | The independent effects of cigarette smoking, alcohol consumption, and serum aspartate aminotransferase on the alanine aminotransferase ratio in korean men for the risk for esophageal cancer | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Heejin Kimm | - |
dc.contributor.googleauthor | Sangwon Kim | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.identifier.doi | 10.3349/ymj.2010.51.3.310 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01226 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 20376881 | - |
dc.subject.keyword | Alcohol | - |
dc.subject.keyword | smoking | - |
dc.subject.keyword | alanine transaminase | - |
dc.subject.keyword | aspartate aminotransferases | - |
dc.subject.keyword | esophageal neoplasms | - |
dc.contributor.alternativeName | Kimm, Hee Jin | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Kimm, Hee Jin | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 310 | - |
dc.citation.endPage | 317 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.51(3) : 310-317, 2010 | - |
dc.identifier.rimsid | 50833 | - |
dc.type.rims | ART | - |
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