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Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer

DC FieldValueLanguage
dc.contributor.author안지영-
dc.date.accessioned2015-04-23T16:42:28Z-
dc.date.available2015-04-23T16:42:28Z-
dc.date.issued2010-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101074-
dc.description.abstractDespite the great interest in mammalian target of rapamycin (mTOR) as a potential anticancer therapy target, the prognostic role of mTOR in gastric cancer has not been elucidated. In this study, we investigated mTOR expression in gastric cancer tissues and in metastatic lymph nodes and examined its association with clinical outcome. A total of 290 patients with pT2b gastric cancer were enrolled in this study. Patients were divided into 3 groups according to metastatic lymph node status: Group 1 contained 96 patients without lymph node metastasis, Group 2 contained 102 patients with a few (1-2) metastatic lymph nodes and Group 3 contained 92 patients with extensive (>16) lymph node metastasis. Phosphorylated mTOR expression was determined immunohistochemically using tissue microarrays. p-mTOR expression was observed in 36.5% of the gastric cancer tissues in Group 1, 39.2% in Group 2 and 60.9% in Group 3. A significant correlation was found between p-mTOR expression in gastric cancer tissues and in metastatic lymph nodes. The Borrmann type in Group 1, perineural invasion and p-mTOR expression in metastatic lymph nodes in Group 2 and p-mTOR expression in metastatic lymph nodes in Group 3 were found to be independent prognostic factors of disease-free survival. The 5-year disease free survival rate of Group 2 patients was 84.4% in negative p-mTOR and 66.1% in positive p-mTOR expression in metastatic lymph nodes (p = 0.015). The 5-year disease free survival rate of Group 3 patients was 37.3% in negative p-mTOR and 14.9% in positive p-mTOR expression in metastatic lymph nodes (p = 0.037). There was a linear correlation between the rate of tumor recurrence and mTOR expression scores in metastatic lymph nodes. In pT2b gastric cancer, p-mTOR expression in gastric cancer is associated with the extent of lymph node metastasis, and p-mTOR expression in metastatic lymph nodes is correlated with poor disease-free survival. mTOR may harbor significant potential for a prognostic biomarker and therapeutic target for gastric cancer treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2904~2913-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/metabolism*-
dc.subject.MESHAdenocarcinoma/secondary-
dc.subject.MESHCell Differentiation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHIntracellular Signaling Peptides and Proteins/metabolism*-
dc.subject.MESHLymph Nodes/metabolism*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/metabolism*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPhosphorylation-
dc.subject.MESHPrognosis-
dc.subject.MESHProtein-Serine-Threonine Kinases/metabolism*-
dc.subject.MESHStomach Neoplasms/metabolism*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTOR Serine-Threonine Kinases-
dc.subject.MESHTissue Array Analysis-
dc.titlePrognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJi Yeong An-
dc.contributor.googleauthorKyoung Mee Kim-
dc.contributor.googleauthorMin Gew Choi-
dc.contributor.googleauthorJae Hyung Noh-
dc.contributor.googleauthorTae Sung Sohn-
dc.contributor.googleauthorJae Moon Bae-
dc.contributor.googleauthorSung Kim-
dc.identifier.doi10.1002/ijc.24872-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02264-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid19739122-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.24872/abstract-
dc.subject.keywordgastric cancer-
dc.subject.keywordp‐mTOR-
dc.subject.keywordprognostic marker-
dc.subject.keywordsurgery-
dc.subject.keywordlymph node metastasis-
dc.contributor.alternativeNameAn, Ji Yeong-
dc.contributor.affiliatedAuthorAn, Ji Yeong-
dc.citation.volume126-
dc.citation.number12-
dc.citation.startPage2904-
dc.citation.endPage2913-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.126(12) : 2904-2913, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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